3-Alkyl-2,4-dinitrocyclohexanols can be prepared in a one-pot procedure by reaction of 1,3-dinitroalkanes with acrolein, catalysed by basic alumina and in the absence of any solvent. The synthesis proceeds using tandem Michael/nitroaldol (Henry) reactions and allows satisfactory to good yields of the title compounds. Moreover, several functionalities can be preserved under our conditions
One-pot Synthesis of 3-alkyl-2,4-dinitrocyclohexanols, Under Solventless Conditions Using Basic Alumina
BALLINI, Roberto;BARBONI, Luciano;FIORINI, Dennis;GIARLO, Guido;PALMIERI, Alessandro
2005-01-01
Abstract
3-Alkyl-2,4-dinitrocyclohexanols can be prepared in a one-pot procedure by reaction of 1,3-dinitroalkanes with acrolein, catalysed by basic alumina and in the absence of any solvent. The synthesis proceeds using tandem Michael/nitroaldol (Henry) reactions and allows satisfactory to good yields of the title compounds. Moreover, several functionalities can be preserved under our conditionsFile in questo prodotto:
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