Nitroalkanes react with chiral acrylates in the presence of a catalytic amount (10% mol) of CTAOH in small amount of water as solvent. Although only modest levels of diastereoselectivity can be observed in this process, the obtained Michael adducts can be easily transformed into interesting building blocks as gamma-amino acids and cyclic hydroxycarbamates.
Michael addition of nitroalkanes to optically active acrylates mediated by cetyltrimethylammonium hydroxide (CTAOH)
BALLINI, Roberto;FIORINI, Dennis;PALMIERI, Alessandro;PETRINI, Marino
2004-01-01
Abstract
Nitroalkanes react with chiral acrylates in the presence of a catalytic amount (10% mol) of CTAOH in small amount of water as solvent. Although only modest levels of diastereoselectivity can be observed in this process, the obtained Michael adducts can be easily transformed into interesting building blocks as gamma-amino acids and cyclic hydroxycarbamates.File in questo prodotto:
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