A heterodinucleotide comprising BVDU and Gemcitabine bound together by a 5',5'-pyrophospate bridge (BVDUp(2)dFdC) has been synthesized and evaluated as antitumor agent against AH13 rat sarcoma cells. BVDUp(2)dFdC showed a cytotoxicity similar to that of Gemcitabine.
Synthesis and antitumor activity of a heterodinucleotide of BVDU and Gemcitabine
CAPPELLACCI, Loredana;FRANCHETTI, Palmarisa;VITA, PATRIZIA;PETRELLI, Riccardo;GRIFANTINI, Mario
2008-01-01
Abstract
A heterodinucleotide comprising BVDU and Gemcitabine bound together by a 5',5'-pyrophospate bridge (BVDUp(2)dFdC) has been synthesized and evaluated as antitumor agent against AH13 rat sarcoma cells. BVDUp(2)dFdC showed a cytotoxicity similar to that of Gemcitabine.File in questo prodotto:
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