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|Titolo:||CAPSAICIN-INDUCED INHIBITION OF MITOGEN AND IL-2-STIMULATED CELL PROLIFERATION:ITS REVERSAL BY IN VIVO SUBSTANCE P ADMINISTRATION.|
|Autori interni:||SANTONI, Giorgio|
PERFUMI, Marina Cecilia
|Data di pubblicazione:||1996|
|Rivista:||JOURNAL OF NEUROIMMUNOLOGY|
|Abstract:||The direct and indirect interaction between the nervous and the immune systems was evaluated in the rat using the neurotoxin capsaicin. Capsaicin treatment of neonatal rats (50 mg/kg at 2 days of age), results in a marked inhibition of mitogen and hrIL-2-induced cell proliferation both in the spleen and peripheral blood. Inhibition is already evident on day 15 after treatment and persists until day 90 in the spleen; at this time a return to control levels is observed in peripheral blood. The inhibition of proliferative response strongly correlates with a decreased number of CD5+ and CD4+ T cells as evaluated by immunofluorescence and FACS analysis. Moreover, continuous in vivo SP administration stimulates mitogen and hrIL-2-induced proliferative response and completely reverts the capsaicin-induced inhibition of lymphocyte proliferation in the spleen.|
|Appare nelle tipologie:||Articolo|
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