Reaction of indazoles with aldehydes in the presence of p-toluenesulfinic acid affords the corresponding sulfonyl indazoles in satisfactory yields. The reported Friedel-Crafts process is rather unusual on indazoles because of the reduced electronic density of the heterocycle. The obtained sulfonyl indazoles can be desulfonylated under reductive conditions, finally leading to 3-alkylated indazoles.
|Titolo:||Synthesis of 3-(Tosylalkyl) Indazoles and their Desulfonylation Reaction. A New Entry to 3-Substituted Indazoles by an Unprecedented Friedel–Crafts Process|
|Autori interni:||PALMIERI, Alessandro|
|Data di pubblicazione:||2009|
|Rivista:||EUROPEAN JOURNAL OF ORGANIC CHEMISTRY|
|Appare nelle tipologie:||Articolo|