Reaction of indazoles with aldehydes in the presence of p-toluenesulfinic acid affords the corresponding sulfonyl indazoles in satisfactory yields. The reported Friedel-Crafts process is rather unusual on indazoles because of the reduced electronic density of the heterocycle. The obtained sulfonyl indazoles can be desulfonylated under reductive conditions, finally leading to 3-alkylated indazoles.
Synthesis of 3-(Tosylalkyl) Indazoles and their Desulfonylation Reaction. A New Entry to 3-Substituted Indazoles by an Unprecedented Friedel–Crafts Process / S., Campetella; Palmieri, Alessandro; Petrini, Marino. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - la rivista non ha numero di volume:19(2009), pp. 3184-3188.
Titolo: | Synthesis of 3-(Tosylalkyl) Indazoles and their Desulfonylation Reaction. A New Entry to 3-Substituted Indazoles by an Unprecedented Friedel–Crafts Process |
Autori: | |
Data di pubblicazione: | 2009 |
Rivista: | |
Citazione: | Synthesis of 3-(Tosylalkyl) Indazoles and their Desulfonylation Reaction. A New Entry to 3-Substituted Indazoles by an Unprecedented Friedel–Crafts Process / S., Campetella; Palmieri, Alessandro; Petrini, Marino. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - STAMPA. - la rivista non ha numero di volume:19(2009), pp. 3184-3188. |
Handle: | http://hdl.handle.net/11581/102679 |
Appare nelle tipologie: | Articolo |
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