Sfoglia per Autore
Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N-6-substituted 3'-C-methyladenosine derivatives
2008-01-01 Cappellacci, Loredana; Franchetti, Palmarisa; Vita, P.; Petrelli, Riccardo; Lavecchia, A.; Jayaram, H. N.; Saiko, P.; Graser, G.; Szekeres, T.; Grifantini, Mario
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y(2) and P2Y(6) receptor agonists
2008-01-01 Ko, H.; Carter, R. L.; Cosyn, L.; Petrelli, Riccardo; DE CASTRO, S.; Besada, P.; Zhou, Y.; Cappellacci, Loredana; Franchetti, P.; Grifantini, M.; VAN CALENBERGH, S.; Harden, T. K.; Jacobson, K. A.
5’-Carbamoyl Derivatives of 2'-C-Methyl-purine Nucleosides as Selective A1 Adenosine Receptor Agonists: Affinity, Efficacy and Selectivity for A1 Receptor from Different Species.
2008-01-01 Cappellacci, Loredana; Franchetti, Palmarisa; Petrelli, Riccardo; Vita, P; Lavecchia, A; Costa, B; Spinetti, F; Martini, C; Klotz, K. N.; Grifantini, Mario
Novel cofactor-type inhibitors of NAD-dependent enzymes. NAD-based therapeutics.
2008-01-01 Chen, L; Petrelli, Riccardo; Felczak, K; Olesiak, M; Rejman, D; Bennett, E. M.; Magni, G; Pankiewicz, Kw
Compact NAD mimics as selective inhibitors of NAD kinases
2009-01-01 Petrelli, Riccardo; Sham, Y. Y.; Chen, L; Felczak, K; DI STEFANO, M; Magni, G; Pankiewicz, K. W.
Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues
2009-01-01 Petrelli, Riccardo; Sham, Yy; Chen, Lq; Felczak, K; Bennett, E; Wilson, D; Aldrich, C; Yu, Js; Cappellacci, Loredana; Franchetti, P; Grifantini, M; Mazzola, F; DI STEFANO, M; Magni, G; Pankiewicz, Kw
New N6-substituted adenosine and 3’-C-methyl-adenosine derivatives as antitumor agents
2009-01-01 Cappellacci, Loredana; Petrelli, Riccardo; Vita, Patrizia; Franchetti, Palmarisa; Kusumanchi, P; Kumar, M; Jayaram, Hn; Grifantini, Mario
“Third Joint Italian-German Purine Club Meeting - Purinergic Receptors: New Frontiers for Novel Therapies”
2009-01-01 Cristalli, Gloria; Buccioni, Michela; Cappellacci, Loredana; DAL BEN, Diego; Lambertucci, Catia; Marucci, Gabriella; Petrelli, Riccardo; Volpini, Rosaria
5'-Chloro-5'-deoxy-N6-(±)-endo-norbornyladenosine, a potent and highly selective human A1 adenosine receptor agonist modulates neuropathic pain in mice.
2009-01-01 Livio, Luongo; Cappellacci, Loredana; Enza, Palazzo; Claudia, Rossi; Vita, Patrizia; Petrelli, Riccardo; Grifantini, Mario; Sabatino, Maione
N6-Cycloalkyl- and N6-Bicycloalkyl-C5′(C2′)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A(1) Adenosine Receptor with Antinociceptive Effects in Mice
2009-01-01 Franchetti, P; Cappellacci, Loredana; Vita, P; Petrelli, Riccardo; Lavecchia, A; Kachler, S; Klotz, K. N.; Marabase, I; Luongo, L; Maione, S; Grifantini, M.
Selective inhibition of nicotinamide adenine kinases (NADKs) by compact NAD mimics
2009-01-01 Petrelli, Riccardo; Felczak, K; Chen, L; Vita, Patrizia; Cappellacci, Loredana; Franchetti, Palmarisa; Grifantini, Mario; Di Stefano, M; Magni, G; Pankiewicz, K.
5'-CHLORO-5'-DEOXY-N6-(±)-endo-NORBORNYLADENOSINE, A POTENT AND HIGHLY SELECTIVE HUMAN A1 ADENOSINE RECEPTOR AGONIST, PREVENTS HYPERALGESIA/ALLODYNIA AND EARLY OVER-EXPRESSION OF PRO-APOPTOTIC AND PRO-INFLAMMATORY GENES IN A MICE MODEL OF NEUROPATHIC PAIN
2010-01-01 V., De Novellis; Cappellacci, Loredana; L., Luongo; Vita, Patrizia; Petrelli, Riccardo; Grifantini, Mario; S., Maione
EFFECTS OF METAL(III) COORDINATION ON BIOLOGICAL ACTIVITY OF 2,2'-BIPYRIDYL-6-CARBOTHIOAMIDE (BPYTA), A POTENT R2 RIBONUCLEOTIDE REDUCTASE INHIBITOR
2010-01-01 Cappellacci, Loredana; Petrelli, Riccardo; Vita, Patrizia; Grifantini, Mario; Heffeter P., Kowol CR; Franchetti, Palmarisa
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure
2010-01-01 Chen, L. Q.; Petrelli, Riccardo; Gao, G. Y.; Wilson, D. J.; Mclean, G. T.; Jayaram, H. N.; Sham, Y. Y.; Pankiewicz, K. W.
Dual-target dimeric molecules with antitumor properties. Synthesis and biological activity of 3’-C-methyladenosine-valproates
2010-01-01 Cappellacci, Loredana; Petrelli, Riccardo; Vita, Patrizia; Franchetti, Palmarisa; Jayaram, Hn; Grifantini, Mario
Effects of 5'-chloro-5'-deoxy-N6-(±)-endo-norbornyl-adenosine, a potent and highly selective A1 adenosine receptor agonist, on neuropathic pain-induced behavioural and morphological changes in spinal microglia
2010-01-01 Luongo, L; Cappellacci, Loredana; Giordano, C; Petrelli, Riccardo; Guida, F; Franchetti, Palmarisa; Grifantini, Mario; Maione, S.
Antitumor effects of novel co-drugs linking histone deacetylase and ribonucleotide reductase inhibitors in hematological tumors
2011-01-01 A., Ferro; Cappellacci, Loredana; A., Mingrino; Petrelli, Riccardo; M., Tolomeo; Vita, Patrizia; N., D’Alessandro; L., Dusonchet; Franchetti, Palmarisa; Grifantini, Mario; M., Meli
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents
2011-01-01 Cappellacci, Loredana; Petrelli, Riccardo; Franchetti, Palmarisa; Vita, Patrizia; Kusumanchi, P; Kumar, M; Jayaram, H. N.; Zhou, B; Yen, Y; Grifantini, Mario
Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3’-C-methyladenosine in leukaemia cells
2011-01-01 Meli, M; Tolomeo, M; Grifantini, Mario; Mai, A; Cappellacci, Loredana; Petrelli, Riccardo; Rotili, D; Ferro, A; Saiko, P; Szekeres, T; Dusonchet, L.
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain
2011-01-01 Felczak, K.; Chen, L.; Wilson, D.; Williams, J.; Vince, R.; Petrelli, Riccardo; Jayaram, H. N.; Kusumanchi, P.; Kumar, M.; Pankiewicz, K. W.
Titolo | Data di pubblicazione | Autore(i) | Tipo | File |
---|---|---|---|---|
Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N-6-substituted 3'-C-methyladenosine derivatives | 1-gen-2008 | Cappellacci, Loredana; Franchetti, Palmarisa; Vita, P.; Petrelli, Riccardo; Lavecchia, A.; Jayaram, H. N.; Saiko, P.; Graser, G.; Szekeres, T.; Grifantini, Mario | Articolo | |
Synthesis and potency of novel uracil nucleotides and derivatives as P2Y(2) and P2Y(6) receptor agonists | 1-gen-2008 | Ko, H.; Carter, R. L.; Cosyn, L.; Petrelli, Riccardo; DE CASTRO, S.; Besada, P.; Zhou, Y.; Cappellacci, Loredana; Franchetti, P.; Grifantini, M.; VAN CALENBERGH, S.; Harden, T. K.; Jacobson, K. A. | Articolo | |
5’-Carbamoyl Derivatives of 2'-C-Methyl-purine Nucleosides as Selective A1 Adenosine Receptor Agonists: Affinity, Efficacy and Selectivity for A1 Receptor from Different Species. | 1-gen-2008 | Cappellacci, Loredana; Franchetti, Palmarisa; Petrelli, Riccardo; Vita, P; Lavecchia, A; Costa, B; Spinetti, F; Martini, C; Klotz, K. N.; Grifantini, Mario | Articolo | |
Novel cofactor-type inhibitors of NAD-dependent enzymes. NAD-based therapeutics. | 1-gen-2008 | Chen, L; Petrelli, Riccardo; Felczak, K; Olesiak, M; Rejman, D; Bennett, E. M.; Magni, G; Pankiewicz, Kw | Articolo | |
Compact NAD mimics as selective inhibitors of NAD kinases | 1-gen-2009 | Petrelli, Riccardo; Sham, Y. Y.; Chen, L; Felczak, K; DI STEFANO, M; Magni, G; Pankiewicz, K. W. | Poster atto convegno su rivista | |
Selective inhibition of nicotinamide adenine dinucleotide kinases by dinucleoside disulfide mimics of nicotinamide adenine dinucleotide analogues | 1-gen-2009 | Petrelli, Riccardo; Sham, Yy; Chen, Lq; Felczak, K; Bennett, E; Wilson, D; Aldrich, C; Yu, Js; Cappellacci, Loredana; Franchetti, P; Grifantini, M; Mazzola, F; DI STEFANO, M; Magni, G; Pankiewicz, Kw | Articolo | |
New N6-substituted adenosine and 3’-C-methyl-adenosine derivatives as antitumor agents | 1-gen-2009 | Cappellacci, Loredana; Petrelli, Riccardo; Vita, Patrizia; Franchetti, Palmarisa; Kusumanchi, P; Kumar, M; Jayaram, Hn; Grifantini, Mario | Contributo in atto di convegno su volume | |
“Third Joint Italian-German Purine Club Meeting - Purinergic Receptors: New Frontiers for Novel Therapies” | 1-gen-2009 | Cristalli, Gloria; Buccioni, Michela; Cappellacci, Loredana; DAL BEN, Diego; Lambertucci, Catia; Marucci, Gabriella; Petrelli, Riccardo; Volpini, Rosaria | ORGANIZZAZIONE DI EVENTI | |
5'-Chloro-5'-deoxy-N6-(±)-endo-norbornyladenosine, a potent and highly selective human A1 adenosine receptor agonist modulates neuropathic pain in mice. | 1-gen-2009 | Livio, Luongo; Cappellacci, Loredana; Enza, Palazzo; Claudia, Rossi; Vita, Patrizia; Petrelli, Riccardo; Grifantini, Mario; Sabatino, Maione | Poster atto convegno su volume | |
N6-Cycloalkyl- and N6-Bicycloalkyl-C5′(C2′)-modified Adenosine Derivatives as High-Affinity and Selective Agonists at the Human A(1) Adenosine Receptor with Antinociceptive Effects in Mice | 1-gen-2009 | Franchetti, P; Cappellacci, Loredana; Vita, P; Petrelli, Riccardo; Lavecchia, A; Kachler, S; Klotz, K. N.; Marabase, I; Luongo, L; Maione, S; Grifantini, M. | Articolo | |
Selective inhibition of nicotinamide adenine kinases (NADKs) by compact NAD mimics | 1-gen-2009 | Petrelli, Riccardo; Felczak, K; Chen, L; Vita, Patrizia; Cappellacci, Loredana; Franchetti, Palmarisa; Grifantini, Mario; Di Stefano, M; Magni, G; Pankiewicz, K. | Contributo in atto di convegno su volume | |
5'-CHLORO-5'-DEOXY-N6-(±)-endo-NORBORNYLADENOSINE, A POTENT AND HIGHLY SELECTIVE HUMAN A1 ADENOSINE RECEPTOR AGONIST, PREVENTS HYPERALGESIA/ALLODYNIA AND EARLY OVER-EXPRESSION OF PRO-APOPTOTIC AND PRO-INFLAMMATORY GENES IN A MICE MODEL OF NEUROPATHIC PAIN | 1-gen-2010 | V., De Novellis; Cappellacci, Loredana; L., Luongo; Vita, Patrizia; Petrelli, Riccardo; Grifantini, Mario; S., Maione | Contributo in atto di convegno su rivista | |
EFFECTS OF METAL(III) COORDINATION ON BIOLOGICAL ACTIVITY OF 2,2'-BIPYRIDYL-6-CARBOTHIOAMIDE (BPYTA), A POTENT R2 RIBONUCLEOTIDE REDUCTASE INHIBITOR | 1-gen-2010 | Cappellacci, Loredana; Petrelli, Riccardo; Vita, Patrizia; Grifantini, Mario; Heffeter P., Kowol CR; Franchetti, Palmarisa | Poster atto convegno su volume | |
Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure | 1-gen-2010 | Chen, L. Q.; Petrelli, Riccardo; Gao, G. Y.; Wilson, D. J.; Mclean, G. T.; Jayaram, H. N.; Sham, Y. Y.; Pankiewicz, K. W. | Articolo | |
Dual-target dimeric molecules with antitumor properties. Synthesis and biological activity of 3’-C-methyladenosine-valproates | 1-gen-2010 | Cappellacci, Loredana; Petrelli, Riccardo; Vita, Patrizia; Franchetti, Palmarisa; Jayaram, Hn; Grifantini, Mario | Poster atto convegno su volume | |
Effects of 5'-chloro-5'-deoxy-N6-(±)-endo-norbornyl-adenosine, a potent and highly selective A1 adenosine receptor agonist, on neuropathic pain-induced behavioural and morphological changes in spinal microglia | 1-gen-2010 | Luongo, L; Cappellacci, Loredana; Giordano, C; Petrelli, Riccardo; Guida, F; Franchetti, Palmarisa; Grifantini, Mario; Maione, S. | Poster atto convegno su volume | |
Antitumor effects of novel co-drugs linking histone deacetylase and ribonucleotide reductase inhibitors in hematological tumors | 1-gen-2011 | A., Ferro; Cappellacci, Loredana; A., Mingrino; Petrelli, Riccardo; M., Tolomeo; Vita, Patrizia; N., D’Alessandro; L., Dusonchet; Franchetti, Palmarisa; Grifantini, Mario; M., Meli | Poster atto convegno su volume | |
Synthesis and biological activity of novel N6-substituted and 2,N6-disubstituted adenine ribo- and 3'-C-methyl-ribonucleosides as antitumor agents | 1-gen-2011 | Cappellacci, Loredana; Petrelli, Riccardo; Franchetti, Palmarisa; Vita, Patrizia; Kusumanchi, P; Kumar, M; Jayaram, H. N.; Zhou, B; Yen, Y; Grifantini, Mario | Articolo | |
Histone deacetylase inhibition modulates deoxyribonucleotide pools and enhances the antitumor effects of the ribonucleotide reductase inhibitor 3’-C-methyladenosine in leukaemia cells | 1-gen-2011 | Meli, M; Tolomeo, M; Grifantini, Mario; Mai, A; Cappellacci, Loredana; Petrelli, Riccardo; Rotili, D; Ferro, A; Saiko, P; Szekeres, T; Dusonchet, L. | Articolo | |
Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain | 1-gen-2011 | Felczak, K.; Chen, L.; Wilson, D.; Williams, J.; Vince, R.; Petrelli, Riccardo; Jayaram, H. N.; Kusumanchi, P.; Kumar, M.; Pankiewicz, K. W. | Articolo |
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