Novel 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7-tricarboxylates compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7-tricarboxylates compounds, identified as adenosine A3 receptor (A3AR) modulators, are useful as anti-inflammation, anticancer and/or anti-ischemic agents, and as agents for treating other adenosine overexpression related conditions including rheumatoid arthritis, psoriasis and fatty liver diseases, inflammation, pain, and number of pathological conditions of the central and peripheral nervous systems
7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7 tricarboxylates as adenosine receptor active compound
Buccioni M.;Marucci G.;
2023-01-01
Abstract
Novel 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7-tricarboxylates compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The 7-isopropyl 1,2-dimethyl 3-(substituted benzoyl)indolizine-1,2,7-tricarboxylates compounds, identified as adenosine A3 receptor (A3AR) modulators, are useful as anti-inflammation, anticancer and/or anti-ischemic agents, and as agents for treating other adenosine overexpression related conditions including rheumatoid arthritis, psoriasis and fatty liver diseases, inflammation, pain, and number of pathological conditions of the central and peripheral nervous systemsI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
