ROLE OF XENOSIALIZATION IN THE PATHOGENESIS OF COLITIS IN THE CANINE MODEL: POSSIBLE POSITIVE EFFECTS OF NEW PROBIOTICS BLENDS

Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal inflammation with no exact known cause. In dogs, IBD is expressed histologically with lymphoplasmacytic inflammation (LPL) of gastrointestinal tract. The study evaluates the possible correlation between microbiota, dietary absorption,enteric expression of N-glycolylneuraminic acid (Neu5Gc) (xenosialization) and intestinal inflammation (xenosialitis) in dogs with IBD. Neu5Gc is indeed synthesized from its N-acetyl precursor (Neu5Ac) by cytidine-5′-monophospho-N acetylneuraminic acid hydroxylase (CMAH), absent in humans, and polymorphic in dogs.