Lipids as Supporting Therapy in Cancer

The current anticancer chemotherapeutic drugs toxicity and partial efficacy as well as the development of multiple drug resistance are the major problems for some cancer therapies. So, the development of well-tolerated agents with different mode of action on cancer metabolism might be used in combination with chemotherapeutic drugs as an adjuvant therapy. Lipids have been studied as anticancer agents and lipid metabolism is involved in the regulation of many cancers cellular processes such as cell growth, proliferation, survival, apoptosis, inflammation, invasion and drug resistance. Moreover, since lipids metabolism is modulated by multiple signaling pathways and give rise to different bioactive lipid molecules such as fatty acid, eicosanoids, diacylglycerol and many others, lipids metabolism and its derivates has been subject of intense studies for understanding the underlying mechanisms involved in cancer process regulation. Our issue is dedicated to the improvement of the lipids molecular and metabolic interaction events that contribute to reducing carcinogenesis and the identification of novel lipid-regulating pathways able to interfere with carcinogenesis. Therefore, we invite submissions that cover lipids and lipids-derivates anticancer activities, that accompanies all stages of tumor development. We aim to contribute in the identification of novel compounds and potential adjuvant therapies for reducing cancer progression. Our Special Issue also aims to publish papers dealing with the molecular basis of lipids interaction with oncogene and tumor suppressor expression, role in cell cycle and cell death regulation, and all molecular pathways involved in anti-cancer approaches.