The RNA structure, the main predictor of biological function, is the result of the folding process. While the nucleotides in the RNA sequence rapidly coupled forming weak bonds, the spatial arrangement is a slow process. Although many computational approaches have been proposed to study the folding process of RNA, most of them do not consider the hierarchical aspect existing among the bonds. In this work, we propose to collapse nucleotides and bonds underpinning the primary and secondary structure of RNA in a unique label core congruent with the spatial configuration. A label core is represented as a term of generalized context-free grammar properly defined to support RNA structural reduction and analysis.

Label core for understanding RNA structure

Merelli E.
Secondo
;
Piergallini R.
Ultimo
2020

Abstract

The RNA structure, the main predictor of biological function, is the result of the folding process. While the nucleotides in the RNA sequence rapidly coupled forming weak bonds, the spatial arrangement is a slow process. Although many computational approaches have been proposed to study the folding process of RNA, most of them do not consider the hierarchical aspect existing among the bonds. In this work, we propose to collapse nucleotides and bonds underpinning the primary and secondary structure of RNA in a unique label core congruent with the spatial configuration. A label core is represented as a term of generalized context-free grammar properly defined to support RNA structural reduction and analysis.
978-3-030-63060-7
978-3-030-63061-4
File in questo prodotto:
File Dimensione Formato  
20_LNCSCIBB_RNA_labelCore.pdf

embargo fino al 10/12/2021

Descrizione: First Online: 10 December 2020 - Articolo completo
Tipologia: Documento in Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 987.8 kB
Formato Adobe PDF
987.8 kB Adobe PDF Visualizza/Apri
Lecture Notes in Computer Science, 12313 p171.pdf

non disponibili

Tipologia: Versione Editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 590.21 kB
Formato Adobe PDF
590.21 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11581/456558
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 0
  • ???jsp.display-item.citation.isi??? ND
social impact