In recent years the biomedical research has focused on new metal-based anticancer drugs. Among them Cu-based antitumor agents are arising some attention based on the observation that endogenous metals appear to be less toxic toward normal cells with respect to cancer ones. Conjugating the Cu(II) complexes with hydrophilic gold nanoparticles (Au-NPs) appears a promising way, suitable to improve the complexes solubility and stability in water and to raise their bioavailability. In this context, we investigated the valence state and coordination chemistry of Cu for a selection of Cu-complexes suitable for grafting on Au-NPs. The Cu K-edge XAFS data were analysed in the near edge (XANES) and extended (EXAFS) regions to obtain preliminary characterization aimed at understanding local coordination chemistry and electronic structure of Cu.
Chapter 13 - Metal Coordination Core in Copper(II) Complexes Investigated by XAFS
Pellei, Maura;Santini, Carlo;Bagnarelli, Luca;
2021-01-01
Abstract
In recent years the biomedical research has focused on new metal-based anticancer drugs. Among them Cu-based antitumor agents are arising some attention based on the observation that endogenous metals appear to be less toxic toward normal cells with respect to cancer ones. Conjugating the Cu(II) complexes with hydrophilic gold nanoparticles (Au-NPs) appears a promising way, suitable to improve the complexes solubility and stability in water and to raise their bioavailability. In this context, we investigated the valence state and coordination chemistry of Cu for a selection of Cu-complexes suitable for grafting on Au-NPs. The Cu K-edge XAFS data were analysed in the near edge (XANES) and extended (EXAFS) regions to obtain preliminary characterization aimed at understanding local coordination chemistry and electronic structure of Cu.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
