Reactive oxygen species (ROS), including free radicals, are involved in many physiological and pathological events, and the control of their production is modulated by endogenous and exogenous systems, whose final goal is to maintain the redox equilibrium. Several diseases (e.g., neurodegeneration, cancer, cardiovascular diseases, etc.) are associated with an imbalance in this redox control, and biomarkers of oxidation have been correlated with the development of several age-related diseases. In this context, the use of antioxidants, either through dietary intake or supplementation, has been proposed to counterbalance ROS-induced oxidation. The key point, however, is that to date, the proper quantity of antioxidants required to achieve a personalized protective biological response without any pro-oxidant effects is still poorly defined. Furthermore, several human intervention trials with antioxidant supplementation have shown no conclusive evidence to support the use of vitamins and antioxidant supplements for the prevention of redox-related diseases. With this in mind, this Special Issue aims to publish original research papers, systematic reviews, and meta-analyses that contribute to better clarify the complexity related to dose/gender/age responses on antioxidant-protection against the most common diseases linked with oxidative stress.
Antioxidants in Oxidative Stress Diseases
Gabbianelli R;
2019-01-01
Abstract
Reactive oxygen species (ROS), including free radicals, are involved in many physiological and pathological events, and the control of their production is modulated by endogenous and exogenous systems, whose final goal is to maintain the redox equilibrium. Several diseases (e.g., neurodegeneration, cancer, cardiovascular diseases, etc.) are associated with an imbalance in this redox control, and biomarkers of oxidation have been correlated with the development of several age-related diseases. In this context, the use of antioxidants, either through dietary intake or supplementation, has been proposed to counterbalance ROS-induced oxidation. The key point, however, is that to date, the proper quantity of antioxidants required to achieve a personalized protective biological response without any pro-oxidant effects is still poorly defined. Furthermore, several human intervention trials with antioxidant supplementation have shown no conclusive evidence to support the use of vitamins and antioxidant supplements for the prevention of redox-related diseases. With this in mind, this Special Issue aims to publish original research papers, systematic reviews, and meta-analyses that contribute to better clarify the complexity related to dose/gender/age responses on antioxidant-protection against the most common diseases linked with oxidative stress.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
