Diet during the first 1000 days of life can modulate offspring’s epigenome leading to tissue specific epigenetic marks associated with long-term effects on offspring health. Several environmental factors (e.g. diet, chemicals, pesticides, endocrine disruptors, drugs, stress, etc.) are actively involved in the modulation of the epigenome [1,2]. Maternal and neonatal nutrition can influence organ development (i.e. brain, heart, lung) promoting a healthy/unhealthy phenotype in adulthood. Food/environmental pesticides during pregnancy and/or lactation increases the individual risk associated with the development of neurodegeneration in adulthood, while endocrine disruptors have obesogenic properties promoting the development of associated diseases [3,4]. Of particular concern is that epigenetic marks of diseases may be inherited and they can mediate epigenetic inheritance of diseases [5,6]. Appropriate dietary nutrients, as well as dietary flavonoids and other bioactive compounds, can modulate chromatin structure and DNA methylation switching on/off genes properly. Selected foods can control inflammation and maintain a balanced redox state by modulating gene expression and gut microbiota responses toward specific metabolites that affect the epigenome. Therefore, early dietary interventions can modulate nutri-epigenetics towards a healthy status: the “epigenetic memory” of healthy food choices can confer cellular resilience to metabolic perturbations in adult age.

Nutri-epigenetics and health

Gabbianelli Rosita
2019

Abstract

Diet during the first 1000 days of life can modulate offspring’s epigenome leading to tissue specific epigenetic marks associated with long-term effects on offspring health. Several environmental factors (e.g. diet, chemicals, pesticides, endocrine disruptors, drugs, stress, etc.) are actively involved in the modulation of the epigenome [1,2]. Maternal and neonatal nutrition can influence organ development (i.e. brain, heart, lung) promoting a healthy/unhealthy phenotype in adulthood. Food/environmental pesticides during pregnancy and/or lactation increases the individual risk associated with the development of neurodegeneration in adulthood, while endocrine disruptors have obesogenic properties promoting the development of associated diseases [3,4]. Of particular concern is that epigenetic marks of diseases may be inherited and they can mediate epigenetic inheritance of diseases [5,6]. Appropriate dietary nutrients, as well as dietary flavonoids and other bioactive compounds, can modulate chromatin structure and DNA methylation switching on/off genes properly. Selected foods can control inflammation and maintain a balanced redox state by modulating gene expression and gut microbiota responses toward specific metabolites that affect the epigenome. Therefore, early dietary interventions can modulate nutri-epigenetics towards a healthy status: the “epigenetic memory” of healthy food choices can confer cellular resilience to metabolic perturbations in adult age.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11581/430068
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact