Nutri-epigenetics and obesity.

Life style, genetics and the environment interactions play a key role in obesity. Starting from prenatal period of life food intake can modulate epigenome leading to long term effects on health. The first 1000 days of life are the window of epigenetic plasticity to exposome (e.g. diet, environmental chemical, food pesticide, endocrine disruptors, etc), and early epigenetic markers during this phase of life can lead to long term effects on health. Environmental pesticides, can promote preeclampsia reducing the normal uptake of nutrient to the fetus, while endocrine disrupting chemicals increase body weight, affecting adipogenesis, lipid accumulation, inflammation, metabolic syndrome development and gut microbiota composition. This presentation will analyze the impact of exposome on early life programming of adult health, focusing on the factors promoting obese phenotype development and the maternal prenatal and post-natal diet, with the aim to address early preventive strategies to control the development of obesity.