Methods and compositions relating to p62/sqstm for the treatment and prevention of inflammation-associated diseases

Provided herein are novel p62 compositions for the modulation of expression of a proinflammatory cy tokines, osteogenic transcription factors, a bone resorptive factors and endogenous p62. Consequently, such p62 com positions are useful for prophylaxis and treatment of inflam matory diseases and related methods. In certain embodi ments the inflammatory diseases are not cancer-related. In various embodiments, the inflammatory diseases include, but are not limited to osteoporosis, obesity, metabolic syn drome, type 2 diabetes, fat liver, inflammatory bowel dis ease, chronic pancreatitis, asthma, chronic obstructive pul monary disease (COPD), rheumatoid arthritis (RA), os teoarthritis, multiple sclerosis (MS), psoriasis, congestive heart failure (CHF), atherosclerosis, neurodegenerative d i s eases (ALS, Parkinson, Alzheimer's, Huntington disease),de- pression, schizophrenia, gout, asbestosis and silicosis.