Copper complexes represent one of the prospective groups of metal-based drugs proposed as an alternative to platinum drugs in the treatment of cancer. Part I analyzes the route followed by our research group in the syntheses of hydrophilic phosphine–copper(I) complexes. Beyond classical characterization in the solid and solution states, additional physicochemical studies have established the thermodynamic stability of these complexes as copper(I) species in aqueous media. A class of homoleptic phosphine complexes of general formula [Cu(PR3)4]+ (PR3tertiary phosphine) has also disclosed intriguing kinetic lability. Hence, copper(I) can be transchelated from [Cu(PR3)n]+ inorganic scaffolds (n≤4) into amino-acidic sequences typical of copper transporters. Within this approach, we hypothesize that an amount of copper exceeding its normal homeostasis could be selectively loaded into tumor cells for antiproliferative purposes, whilst leaving unaffected nontumor cells.
Phosphine–copper(I) complexes as anticancer agents: design, synthesis, and physicochemical characterization. Part I
Santini, Carlo;
2019-01-01
Abstract
Copper complexes represent one of the prospective groups of metal-based drugs proposed as an alternative to platinum drugs in the treatment of cancer. Part I analyzes the route followed by our research group in the syntheses of hydrophilic phosphine–copper(I) complexes. Beyond classical characterization in the solid and solution states, additional physicochemical studies have established the thermodynamic stability of these complexes as copper(I) species in aqueous media. A class of homoleptic phosphine complexes of general formula [Cu(PR3)4]+ (PR3tertiary phosphine) has also disclosed intriguing kinetic lability. Hence, copper(I) can be transchelated from [Cu(PR3)n]+ inorganic scaffolds (n≤4) into amino-acidic sequences typical of copper transporters. Within this approach, we hypothesize that an amount of copper exceeding its normal homeostasis could be selectively loaded into tumor cells for antiproliferative purposes, whilst leaving unaffected nontumor cells.File | Dimensione | Formato | |
---|---|---|---|
Chapter 3 - Balakrishna-CCP-1631690.pdf
solo gestori di archivio
Descrizione: Articolo principale
Tipologia:
Versione Editoriale
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
510.52 kB
Formato
Adobe PDF
|
510.52 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.