Boron containing carbene complexes have never been investigated till now for their possible applications as anticancer drugs1. Our research group reported the synthesis of coinage metal-NHC complexes obtained from the precursors {[HB(RImH)3]Br2} (R = Benzyl, Mesityl and t-Butyl)2 and {[H2B(BnTzH)2]Br}3. Here we present the synthesis of the new ligand {[H2B(pNO2BnTzH)2]Br}3 and the related coinage carbene complexes. The synthesis of this ligand led to the isolation of the byproduct: {[HTz(pNO2Bn)2]Br}4. This new ligand was also prepared by direct synthesis and used as carbene precursor for the formation of the related Cu(I), Ag(I), and Au(I) mono carbene complexes. Their citotoxicity was evaluated over a panel of human cancerous cell lines and the results are here reported.
Borate Carbene Complexes: Synthesis, Reactivity and Biological Evaluation
MARINELLI, MARIKA;PELLEI, Maura;SANTINI, Carlo
2015-01-01
Abstract
Boron containing carbene complexes have never been investigated till now for their possible applications as anticancer drugs1. Our research group reported the synthesis of coinage metal-NHC complexes obtained from the precursors {[HB(RImH)3]Br2} (R = Benzyl, Mesityl and t-Butyl)2 and {[H2B(BnTzH)2]Br}3. Here we present the synthesis of the new ligand {[H2B(pNO2BnTzH)2]Br}3 and the related coinage carbene complexes. The synthesis of this ligand led to the isolation of the byproduct: {[HTz(pNO2Bn)2]Br}4. This new ligand was also prepared by direct synthesis and used as carbene precursor for the formation of the related Cu(I), Ag(I), and Au(I) mono carbene complexes. Their citotoxicity was evaluated over a panel of human cancerous cell lines and the results are here reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
