The present invention refers to plasmid vectors containing DNA sequences coding for truncated and chimeric forms of p 18Sneu protein, and use thereof in DNA vaccination against Her-2/neu (ErbB-2)-positive tumors that express p185neu protein. Plasmids according to the invention are capable of eliciting a protective immune response which is based on antibody and/or T lymphocyte induction against p185neu protein-expressing tumors. The invention further refers to pharmaceutical compositions containing such plasmids and use thereof in preventive or therapeutic treatment of p185neu-19 positive tumors.
Plasmids coding for p185neu protein sequence variants and therapeutic uses thereof
AMICI, Augusto;MARCHINI, Cristina;
2011-01-01
Abstract
The present invention refers to plasmid vectors containing DNA sequences coding for truncated and chimeric forms of p 18Sneu protein, and use thereof in DNA vaccination against Her-2/neu (ErbB-2)-positive tumors that express p185neu protein. Plasmids according to the invention are capable of eliciting a protective immune response which is based on antibody and/or T lymphocyte induction against p185neu protein-expressing tumors. The invention further refers to pharmaceutical compositions containing such plasmids and use thereof in preventive or therapeutic treatment of p185neu-19 positive tumors.File in questo prodotto:
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