Early life environmental exposure could represent a critical period for the onset of permanent alterations in the structure and function of different organs and induces a stronger chronic inflammation, exacerbating the common age related diseases as well as an immune system depression in oldness. We evaluate the effect of early life permethrin treatment (1/50 LD50, from 6th to 21st day of life) on heart of adult rats and on several immune system and inflammation mediators as Nurr-1, NF-kB p65 and Nrf-2 leukocyte proteins expression in adult and old rats. Increased DNA damage, decrease in plasma membrane fluidity, increase in cholesterol content, protein and lipid oxidation have been measured in cardiac cells population from adulthood rats treated with permethrin in neonatal period. Moreover the treatment with pesticide induced higher level of cholesterol, IL-1, IL-2, IFN-rat-Rantes and IL-10 cytokines and decreased albumin content in plasma of rats. Lower cholesterol level and perturbation in the phospholipid lateral diffusion together with a decrease in GSH level and increase in GPx activity were measured in heart mitochondria from treated group. At leukocyte level we observed that Nurr1 protein level, as well as, lipid hydroperoxides and vitamin D plasma concentration increased, while inflammatory cytokines as IL-1, IL-2, IL-13, catecholamines as adrenalin and noradrenalin, and plasma levels decreased with respect to the control group. The results confirm the hypothesis that early life environmental exposure to xenobiotics represents a crucial period for the onset of permanent alterations in the structure and function of different organs and body systems as immune system whose changes will influence the health status in oldness.

Heart Damage And Increase Of Inflammatory Mediators In Rats Following Early Life Pesticide Treatment

FEDELI, Donatella;NASUTI, Cinzia Carla;CARLONI, Manuel;MONTANI, Maura;AMICI, Augusto;GABBIANELLI, Rosita
2011

Abstract

Early life environmental exposure could represent a critical period for the onset of permanent alterations in the structure and function of different organs and induces a stronger chronic inflammation, exacerbating the common age related diseases as well as an immune system depression in oldness. We evaluate the effect of early life permethrin treatment (1/50 LD50, from 6th to 21st day of life) on heart of adult rats and on several immune system and inflammation mediators as Nurr-1, NF-kB p65 and Nrf-2 leukocyte proteins expression in adult and old rats. Increased DNA damage, decrease in plasma membrane fluidity, increase in cholesterol content, protein and lipid oxidation have been measured in cardiac cells population from adulthood rats treated with permethrin in neonatal period. Moreover the treatment with pesticide induced higher level of cholesterol, IL-1, IL-2, IFN-rat-Rantes and IL-10 cytokines and decreased albumin content in plasma of rats. Lower cholesterol level and perturbation in the phospholipid lateral diffusion together with a decrease in GSH level and increase in GPx activity were measured in heart mitochondria from treated group. At leukocyte level we observed that Nurr1 protein level, as well as, lipid hydroperoxides and vitamin D plasma concentration increased, while inflammatory cytokines as IL-1, IL-2, IL-13, catecholamines as adrenalin and noradrenalin, and plasma levels decreased with respect to the control group. The results confirm the hypothesis that early life environmental exposure to xenobiotics represents a crucial period for the onset of permanent alterations in the structure and function of different organs and body systems as immune system whose changes will influence the health status in oldness.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11581/360784
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