Environmental factors interface the genotype-phenotype correlation and result conferring a stable memory of activity status of genes. Early-life exposure (postnatal day 6-21) to low doses of the pesticide permethrin leads to down regulation of Nurr1 expression and also dopamine levels. This is correlated with hyper methylation of CpG in the promoter region of Nurr1 in adolescent rats exposed to permethrin while no alteration in methylation was seen in the age-matched control group. In order to define the mechanisms associated with the decreased Nurr1 gene expression, DNMTs and -synuclein levels were measured in adolescent, adult and old rats. The results obtained confirm their imbalance depending on the treatment and the age of rats.
α-synuclein and DNMT imbalance, following early life permethrin treatment, leads to Nurr1 down regulation
GABBIANELLI, Rosita;FEDELI, Donatella;MONTANI, Maura;NASUTI, Cinzia Carla;
2014-01-01
Abstract
Environmental factors interface the genotype-phenotype correlation and result conferring a stable memory of activity status of genes. Early-life exposure (postnatal day 6-21) to low doses of the pesticide permethrin leads to down regulation of Nurr1 expression and also dopamine levels. This is correlated with hyper methylation of CpG in the promoter region of Nurr1 in adolescent rats exposed to permethrin while no alteration in methylation was seen in the age-matched control group. In order to define the mechanisms associated with the decreased Nurr1 gene expression, DNMTs and -synuclein levels were measured in adolescent, adult and old rats. The results obtained confirm their imbalance depending on the treatment and the age of rats.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
