Hydrazones are an interesting class of Schiff’s bases thanks to their antimicrobial, anticonvulsant, analgesic and anti-inflammatory properties. Ru(II)-arene complexes have been widely taken into account for their potent and selective antitumoral activity. In the present work we exploit the coordination of hydrazone ligands to half-sandwich η6-arene Ru(II) derivatives for enhancing their antibacterial and anticancer properties. As a development of our previous work on ruthenium arene fragments coordinated to 4-acyl-5- pyrazolone and β-ketoamine ligands, we report the synthesis and full characterization of novel Ru(II)-arene complexes (arene = p-cymene, benzene or hexamethylbenzene) containing new hydrazone ligands with general structure HL’. Recent results on their biological activity will be reported.

Coordination of Hydrazone Ligands to Arene Ruthenium(II) Derivatives: Synthesis, Characterization and Bioactivity

CONDELLO, FRANCESCA;ORBISAGLIA, SERENA;PALMUCCI, JESSICA;PETRINI, Agnese;PETRELLI, Riccardo;CAPPELLACCI, Loredana;LUPIDI, Giulio;PETTINARI, Riccardo;MARCHETTI, Fabio;PETTINARI, Claudio
2014-01-01

Abstract

Hydrazones are an interesting class of Schiff’s bases thanks to their antimicrobial, anticonvulsant, analgesic and anti-inflammatory properties. Ru(II)-arene complexes have been widely taken into account for their potent and selective antitumoral activity. In the present work we exploit the coordination of hydrazone ligands to half-sandwich η6-arene Ru(II) derivatives for enhancing their antibacterial and anticancer properties. As a development of our previous work on ruthenium arene fragments coordinated to 4-acyl-5- pyrazolone and β-ketoamine ligands, we report the synthesis and full characterization of novel Ru(II)-arene complexes (arene = p-cymene, benzene or hexamethylbenzene) containing new hydrazone ligands with general structure HL’. Recent results on their biological activity will be reported.
2014
9788867680177
275
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/322982
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