Among the variety of copper-based compounds synthetized so far for application in pharmaceutical studies, phosphine copper(l) compounds of "CuP4" stoichiometry represent a class of promising candidates as antitumor agents. The monocationic copper(I) complex [Cu(thp)4][PF6], highly soluble and stable in water solution, has been designed and investigated with the aim of discovering an alternative metallodrug to cisplatin showing advantage either in terms of drug resistance overcoming and lower toxicity.

Novel phosphine copper complexes for the management of solid malignancies

SANTINI, Carlo;PELLEI, Maura;
2012-01-01

Abstract

Among the variety of copper-based compounds synthetized so far for application in pharmaceutical studies, phosphine copper(l) compounds of "CuP4" stoichiometry represent a class of promising candidates as antitumor agents. The monocationic copper(I) complex [Cu(thp)4][PF6], highly soluble and stable in water solution, has been designed and investigated with the aim of discovering an alternative metallodrug to cisplatin showing advantage either in terms of drug resistance overcoming and lower toxicity.
2012
9788433854186
273
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/317781
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact