Gliomas are primary brain tumours believed to arise from glial cells or their progenitors. They account for 78% of malignant brain tumours . The vast majority of gliomas is high-grade glioblastoma multiforme (GBM), and is characterized by almost unrestrained growth. Consequently, the median survival of patients with GBM was approximately 12 months. While research has generated abundant information regarding the growth characteristics of these cancers, clinical care remains palliative and the prognosis dismal. Gliomagenesis and progression are complex processes only partly understood. At molecular level, tumor progression and the associated heterogeneity is likely the result of multiple mutations in certain key signaling proteins . Among these proteins, the Transient Receptor Potential (TRP) channel family has been identified to profoundly affect a variety of physiological and pathological processes. Members of TRP channels control cellular homeostasis by regulating calcium flux, cell proliferation, differentiation and apoptosis; moreover, in the last years an additional role for TRP ion channel family in malignant cancer growth and progression has been recognized. Approximately thirty TRPs have been identified to date, and are classified in seven different families: TRPC (Canonical), TRPV (Vanilloid), TRPM (Melastatin), TRPML (Mucolipin), TRPP (Polycystin), and TRPA (Ankyrin transmembrane protein) and TRPN (NomPC-like)
New Insight on the Role of Transient Receptor Potential (TRP) Channels in Driven Gliomagenesis PathwaysGlioma - Exploring Its Biology and Practical Relevance
SANTONI, Giorgio;AMANTINI, Consuelo;NABISSI, MASSIMO
2011-01-01
Abstract
Gliomas are primary brain tumours believed to arise from glial cells or their progenitors. They account for 78% of malignant brain tumours . The vast majority of gliomas is high-grade glioblastoma multiforme (GBM), and is characterized by almost unrestrained growth. Consequently, the median survival of patients with GBM was approximately 12 months. While research has generated abundant information regarding the growth characteristics of these cancers, clinical care remains palliative and the prognosis dismal. Gliomagenesis and progression are complex processes only partly understood. At molecular level, tumor progression and the associated heterogeneity is likely the result of multiple mutations in certain key signaling proteins . Among these proteins, the Transient Receptor Potential (TRP) channel family has been identified to profoundly affect a variety of physiological and pathological processes. Members of TRP channels control cellular homeostasis by regulating calcium flux, cell proliferation, differentiation and apoptosis; moreover, in the last years an additional role for TRP ion channel family in malignant cancer growth and progression has been recognized. Approximately thirty TRPs have been identified to date, and are classified in seven different families: TRPC (Canonical), TRPV (Vanilloid), TRPM (Melastatin), TRPML (Mucolipin), TRPP (Polycystin), and TRPA (Ankyrin transmembrane protein) and TRPN (NomPC-like)I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
