Thyroid C-cell carcinoma in sheep is a rare tumor. In one sheep, from a group of six ewes, experimentally infected eighteen months ago with an isolate Maedi/Visna virus, medullary carcinoma was delivered in the right thyroid lobe at necropsy. Neither metastases nor other neoplastic growth were seen. Histological examens were carried out with HE, PAS-reaction and Alkaline Congo Red. The results showed a solid pattern with a connective network which apparead focally enlarged by presence of an amorphous substance. Positiveness to Congo Red staining confirmed its amyloid nature (APUD-Amyloid). Amyloid, which was not seen in previous case reported in the sheep, may be related to an abnormal production of prohormonal amino acidic sequences. Hyperplasia of C-cells was noticed in the remaining glandular tissue of both thyroid lobes. Immunohistochemical investigations were carried out with mono and polyclonal antibodies to the following antigens: calcitonin, neuron specific enolase (yy-NSE), synapthophysin, cytokeratins, neurofilaments, thyroglobulin and vimentin. The results pointed out in neoplastic and hyperplastic cells positiveness for calcitonin, NSE, synaptophysin, cytokeratins and negativeness for neurofilaments, thyroglobulin and vimentin. Synaptophysin, as delivered in previous case (Wiedemann, 1986) apparead to be a good marker for neuroendocrine tumours.

Thyroid C-cell carcinoma in a sheep.

RENZONI, Giacomo;ROSSI, Giacomo;
1994

Abstract

Thyroid C-cell carcinoma in sheep is a rare tumor. In one sheep, from a group of six ewes, experimentally infected eighteen months ago with an isolate Maedi/Visna virus, medullary carcinoma was delivered in the right thyroid lobe at necropsy. Neither metastases nor other neoplastic growth were seen. Histological examens were carried out with HE, PAS-reaction and Alkaline Congo Red. The results showed a solid pattern with a connective network which apparead focally enlarged by presence of an amorphous substance. Positiveness to Congo Red staining confirmed its amyloid nature (APUD-Amyloid). Amyloid, which was not seen in previous case reported in the sheep, may be related to an abnormal production of prohormonal amino acidic sequences. Hyperplasia of C-cells was noticed in the remaining glandular tissue of both thyroid lobes. Immunohistochemical investigations were carried out with mono and polyclonal antibodies to the following antigens: calcitonin, neuron specific enolase (yy-NSE), synapthophysin, cytokeratins, neurofilaments, thyroglobulin and vimentin. The results pointed out in neoplastic and hyperplastic cells positiveness for calcitonin, NSE, synaptophysin, cytokeratins and negativeness for neurofilaments, thyroglobulin and vimentin. Synaptophysin, as delivered in previous case (Wiedemann, 1986) apparead to be a good marker for neuroendocrine tumours.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11581/242182
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