Proventricular Dilatation Disease (PDD) is a deadly wasting syndrome that affl icts wild and domesticated birds and parrots worldwide. The symptoms of PDD are varied, and its outcome is fatal. There is currently no treatment for PDD. The Avian Bornavirus (ABV) is the fi rst candidate in the list of the aetiological agent of PDD. However, the virus was regularly found in clinically healthy birds. This implicates that additional factors for the development of PDD are likely. In our previous studies we have demonstrated that i) sera of PDD-affected parrots showed auto-antibodies to gangliosides; ii) these auto-antibodies are localized in the crop or gastrointestinal ganglia of parrots that, in some cases, are positive also for ABV PCR or P40 antibodies. In our opinion an immunomodulating therapeutical approach is request, for host’s gangliosides antigens desensitization. We report preliminary data regarding a new therapy performed in severely affected birds.

PDD: a possibile new therapeutical approach!

ROSSI, Giacomo;
2012

Abstract

Proventricular Dilatation Disease (PDD) is a deadly wasting syndrome that affl icts wild and domesticated birds and parrots worldwide. The symptoms of PDD are varied, and its outcome is fatal. There is currently no treatment for PDD. The Avian Bornavirus (ABV) is the fi rst candidate in the list of the aetiological agent of PDD. However, the virus was regularly found in clinically healthy birds. This implicates that additional factors for the development of PDD are likely. In our previous studies we have demonstrated that i) sera of PDD-affected parrots showed auto-antibodies to gangliosides; ii) these auto-antibodies are localized in the crop or gastrointestinal ganglia of parrots that, in some cases, are positive also for ABV PCR or P40 antibodies. In our opinion an immunomodulating therapeutical approach is request, for host’s gangliosides antigens desensitization. We report preliminary data regarding a new therapy performed in severely affected birds.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11581/242073
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