Plasmids containing sequences encoding different fragments of p185neu oncoprotein, able to induce an immune response against tulours expressing oncogenes of the ErbB family, and pharmaceutical compositions thereof. The present invention relates to plasmid vectors containing p185neu-encoding sequences and the use thereof in DNA vaccination against tumours. The plasmids according to the invention contain sequences encoding different fragments of human or rat oncoprotein p185neu and are able to induce a humoral or cell-mediated immune response against tumours expressing oncogenes of the ErbB family. The invention also relates to pharmaceutical compositions containing said plasmids and their use for prevention or therapy of p185neu-expressing tumours.
p185neu encoding DNA and therapeuticaluses thereof
AMICI, Augusto;MARCHINI, Cristina
2010-01-01
Abstract
Plasmids containing sequences encoding different fragments of p185neu oncoprotein, able to induce an immune response against tulours expressing oncogenes of the ErbB family, and pharmaceutical compositions thereof. The present invention relates to plasmid vectors containing p185neu-encoding sequences and the use thereof in DNA vaccination against tumours. The plasmids according to the invention contain sequences encoding different fragments of human or rat oncoprotein p185neu and are able to induce a humoral or cell-mediated immune response against tumours expressing oncogenes of the ErbB family. The invention also relates to pharmaceutical compositions containing said plasmids and their use for prevention or therapy of p185neu-expressing tumours.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
