DNA plasmids containing sequences coding for different fragments of 185neu oncoprotein which are able to induce an immune response against p185neu-overex- pressing tumors, and pharmaceutical compositions thereof are described.The present invention refers to plasmid vectors containing DNA sequences coding for truncated and chimeric forms of p 185neu protein, and use thereof in DNA vaccination against Her-2/neu (ErbB-2)-positive tumors that express p185neu protein. Plasmids according to the invention are capable of eliciting a protective immune response which is based on antibody and/or T lymphocyte induction against p185neu protein-expressing tumors. The invention further refers to pharmaceutical compositions containing such plasmids and use thereof in preventive or therapeutic treatment of p185neu-positive tumors.
Plasmids coding for p185neu protein sequence variants and therapeutic uses thereof
AMICI, Augusto;MARCHINI, Cristina;
2008-01-01
Abstract
DNA plasmids containing sequences coding for different fragments of 185neu oncoprotein which are able to induce an immune response against p185neu-overex- pressing tumors, and pharmaceutical compositions thereof are described.The present invention refers to plasmid vectors containing DNA sequences coding for truncated and chimeric forms of p 185neu protein, and use thereof in DNA vaccination against Her-2/neu (ErbB-2)-positive tumors that express p185neu protein. Plasmids according to the invention are capable of eliciting a protective immune response which is based on antibody and/or T lymphocyte induction against p185neu protein-expressing tumors. The invention further refers to pharmaceutical compositions containing such plasmids and use thereof in preventive or therapeutic treatment of p185neu-positive tumors.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.