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EnglishDNA plasmids containing sequences coding for different fragments of 185neu oncoprotein which are able to induce an immune response against p185neu-overex- pressing tumors, and pharmaceutical compositions thereof are described.The present invention refers to plasmid vectors containing DNA sequences coding for truncated and chimeric forms of p 185neu protein, and use thereof in DNA vaccination against Her-2/neu (ErbB-2)-positive tumors that express p185neu protein. Plasmids according to the invention are capable of eliciting a protective immune response which is based on antibody and/or T lymphocyte induction against p185neu protein-expressing tumors. The invention further refers to pharmaceutical compositions containing such plasmids and use thereof in preventive or therapeutic treatment of p185neu-positive tumors.
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| Titolo: | Plasmids coding for p185neu protein sequence variants and therapeutic uses thereof | |
| Autori: | ||
| Data di pubblicazione: | 2008 | |
| Abstract: | DNA plasmids containing sequences coding for different fragments of 185neu oncoprotein which are able to induce an immune response against p185neu-overex- pressing tumors, and pharmaceutical compositions thereof are described.The present invention refers to plasmid vectors containing DNA sequences coding for truncated and chimeric forms of p 185neu protein, and use thereof in DNA vaccination against Her-2/neu (ErbB-2)-positive tumors that express p185neu protein. Plasmids according to the invention are capable of eliciting a protective immune response which is based on antibody and/or T lymphocyte induction against p185neu protein-expressing tumors. The invention further refers to pharmaceutical compositions containing such plasmids and use thereof in preventive or therapeutic treatment of p185neu-positive tumors. | |
| Handle: | http://hdl.handle.net/11581/230063 | |
| Appare nelle tipologie: | 07 BREVETTO |
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