Our work focuses on bone remodeling with a multiscale breadth that ranges from modeling intracellular and inter- cellular RANK/RANKL signaling to tissue dynamics. Sev- eral important findings provide clear evidences of the multi- scale properties of bone formation and of the links between RANK/RANKL and bone density in health and disease con- ditions. Recent studies indicate that the circulating levels of OPG and RANKL are inversely related to bone turnover and bone mineral density (BMD) and contribute to the de- velopment of osteoporosis in postmenopausal women, and thalassemia-induced osteoporosis. We make use of a spa- tial process algebra, the Shape Calculus, to control stochas- tic cell agents that are continuously remodeling the bone. We found that our description is effective for such multi- scale, multilevel process and that RANKL signaling little dynamic concentration defects are greatly amplified by the continuous alternation of absorption and formation resulting in large structural bone defects.

Osteoporosis: a multiscale modeling viewpoint

PAOLETTI, Nicola;MERELLI, Emanuela;
2011

Abstract

Our work focuses on bone remodeling with a multiscale breadth that ranges from modeling intracellular and inter- cellular RANK/RANKL signaling to tissue dynamics. Sev- eral important findings provide clear evidences of the multi- scale properties of bone formation and of the links between RANK/RANKL and bone density in health and disease con- ditions. Recent studies indicate that the circulating levels of OPG and RANKL are inversely related to bone turnover and bone mineral density (BMD) and contribute to the de- velopment of osteoporosis in postmenopausal women, and thalassemia-induced osteoporosis. We make use of a spa- tial process algebra, the Shape Calculus, to control stochas- tic cell agents that are continuously remodeling the bone. We found that our description is effective for such multi- scale, multilevel process and that RANKL signaling little dynamic concentration defects are greatly amplified by the continuous alternation of absorption and formation resulting in large structural bone defects.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11581/226871
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