Our work focuses on bone remodeling with a multiscale breadth that ranges from modeling intracellular and inter- cellular RANK/RANKL signaling to tissue dynamics. Sev- eral important findings provide clear evidences of the multi- scale properties of bone formation and of the links between RANK/RANKL and bone density in health and disease con- ditions. Recent studies indicate that the circulating levels of OPG and RANKL are inversely related to bone turnover and bone mineral density (BMD) and contribute to the de- velopment of osteoporosis in postmenopausal women, and thalassemia-induced osteoporosis. We make use of a spa- tial process algebra, the Shape Calculus, to control stochas- tic cell agents that are continuously remodeling the bone. We found that our description is effective for such multi- scale, multilevel process and that RANKL signaling little dynamic concentration defects are greatly amplified by the continuous alternation of absorption and formation resulting in large structural bone defects.
Osteoporosis: a multiscale modeling viewpoint
PAOLETTI, Nicola;MERELLI, Emanuela;
2011
Abstract
Our work focuses on bone remodeling with a multiscale breadth that ranges from modeling intracellular and inter- cellular RANK/RANKL signaling to tissue dynamics. Sev- eral important findings provide clear evidences of the multi- scale properties of bone formation and of the links between RANK/RANKL and bone density in health and disease con- ditions. Recent studies indicate that the circulating levels of OPG and RANKL are inversely related to bone turnover and bone mineral density (BMD) and contribute to the de- velopment of osteoporosis in postmenopausal women, and thalassemia-induced osteoporosis. We make use of a spa- tial process algebra, the Shape Calculus, to control stochas- tic cell agents that are continuously remodeling the bone. We found that our description is effective for such multi- scale, multilevel process and that RANKL signaling little dynamic concentration defects are greatly amplified by the continuous alternation of absorption and formation resulting in large structural bone defects.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
