The present invention relates to plasmid vectors containing p185neu - encoding sequences and the use thereof in DNA vaccination against tumours. The plasmids according to the invention contain sequences encoding different fragments of human or rat oncoprotein p185neu and are able to induce a humoral or cell-mediated immune response against tumours expressing oncogenes of the ErbB family. The invention also relates to pharmaceutical compositions containing said plasmids and their use for the prevention or therapy of p185neu-expressing tumours.
p185neu-Encoding DNA and therapeutical uses thereof
AMICI, Augusto;MARCHINI, Cristina;
2005-01-01
Abstract
The present invention relates to plasmid vectors containing p185neu - encoding sequences and the use thereof in DNA vaccination against tumours. The plasmids according to the invention contain sequences encoding different fragments of human or rat oncoprotein p185neu and are able to induce a humoral or cell-mediated immune response against tumours expressing oncogenes of the ErbB family. The invention also relates to pharmaceutical compositions containing said plasmids and their use for the prevention or therapy of p185neu-expressing tumours.File in questo prodotto:
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