A cell consists of a large number of components interact- ing in a dynamic environment. The complexity of interaction among cell components and functions makes design of cell simulations a challenging task for biologists. We posit that the paradigm of agent-oriented soft- ware engineering (AOSE), in which complex systems are organized as autonomous software entities (agents) situated in an environment and communicating via high-level languages and protocols (ontologies), may be a natural approach for such models. To evaluate this approach, we constructed a model of cell components involved in the metabolic path- way of carbohydrate oxidation. The agent-oriented organization proved natural and useful in representing three different views of the cell system (functional, dynamic, and static structural) and in supporting bioscien- tists querying a system very close to their mental model.

A Multi-Agent System for Modelling Carbohydrate Oxidation in Cell

CORRADINI, Flavio;MERELLI, Emanuela;
2005-01-01

Abstract

A cell consists of a large number of components interact- ing in a dynamic environment. The complexity of interaction among cell components and functions makes design of cell simulations a challenging task for biologists. We posit that the paradigm of agent-oriented soft- ware engineering (AOSE), in which complex systems are organized as autonomous software entities (agents) situated in an environment and communicating via high-level languages and protocols (ontologies), may be a natural approach for such models. To evaluate this approach, we constructed a model of cell components involved in the metabolic path- way of carbohydrate oxidation. The agent-oriented organization proved natural and useful in representing three different views of the cell system (functional, dynamic, and static structural) and in supporting bioscien- tists querying a system very close to their mental model.
2005
9783540258612
273
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/100499
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 9
social impact