| Nome |
# |
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An Efficient Lewis Acid Catalyzed Povarov Reaction for the One-Pot Stereocontrolled Synthesis of Polyfunctionalized Tetrahydroquinolines, file e0ff0073-040a-9bac-e053-1705fe0af019
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230
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Receptor Ligands as Helping Hands to L-DOPA in the Treatment of Parkinson's Disease, file e0ff0074-3e75-9bac-e053-1705fe0af019
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157
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Exploring the Role of N6‐Substituents in Potent Dual Acting 5'‐C‐Ethyltetrazolyladenosine Derivatives: Synthesis, Binding, Functional Assays, and Antinociceptive Effects in Mice, file e0ff0074-4d08-9bac-e053-1705fe0af019
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122
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Ethylenedioxy homologs of N-methyl-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) and its corresponding cathinone analog methylenedioxymethcathinone: Interactions with transporters for serotonin, dopamine, and norepinephrine, file e0ff0073-7f7d-9bac-e053-1705fe0af019
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121
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TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation, file e0ff0073-b523-9bac-e053-1705fe0af019
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119
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Novel antitumor copper(ii) complexes designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity, file e0ff0074-139c-9bac-e053-1705fe0af019
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111
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The 2-substituted imidazoline ring linked to an aromatic moiety by a biatomic bridge: a bioversatile scaffold, file e0ff0074-619a-9bac-e053-1705fe0af019
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77
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Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation, file e0ff0072-8ce2-9bac-e053-1705fe0af019
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71
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Novel Potent Muscarinic Receptor Antagonists: Investigation on the Nature of Lipophilic Substituents in the 5- and/or 6-Positions of the 1,4-Dioxane Nucleus, file c3101ecb-6b20-40f2-b1d6-47b704d728fa
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51
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Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents, file e0ff0074-c4de-9bac-e053-1705fe0af019
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47
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1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity, file e0ff0075-1132-9bac-e053-1705fe0af019
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35
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An Efficient Lewis Acid Catalyzed Povarov Reaction for the One-Pot Stereocontrolled Synthesis of Polyfunctionalized Tetrahydroquinolines, file e0ff0073-aef3-9bac-e053-1705fe0af019
|
25
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Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia, file e0ff0075-1649-9bac-e053-1705fe0af019
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25
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Scaffold Hybridization Strategy Leads to the Discovery of Dopamine D3Receptor-Selective or Multitarget Bitopic Ligands Potentially Useful for Central Nervous System Disorders, file 713b8a50-bb14-479c-9c07-4fe62adabda4
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17
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Novel highly potent and selective sigma1 receptor antagonists effectively block the binge eating episode in female rats, file 48ada94e-9fbd-4128-8dbe-c65996136a95
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15
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Adenosine receptors as promising targets for the management of ocular diseases, file e0ff0074-ad1b-9bac-e053-1705fe0af019
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10
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Cu(I) and Cu(II) Complexes Based on Lonidamine-Conjugated Ligands Designed to Promote Synergistic Antitumor Effects, file e0ff0074-ff14-9bac-e053-1705fe0af019
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10
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Synthesis of Triazole-Linked Analogues of c‐di-GMP and Their Interactions with Diguanylate Cyclase, file e0ff0072-6760-9bac-e053-1705fe0af019
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9
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Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells, file e0ff0074-2b92-9bac-e053-1705fe0af019
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9
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Effects of allyphenyline on chronic alcohol intoxication model, file e0ff0072-a897-9bac-e053-1705fe0af019
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8
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Antagonism/Agonism modulation to build novel antihypertensives selectively triggering i1-imidazoline receptor activation, file e0ff0074-4c03-9bac-e053-1705fe0af019
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8
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Synthesis and cytotoxic activity evaluation of new Cu(I) complexes of bis(pyrazol-1-yl) acetate ligands functionalized with an NMDA receptor antagonist, file e0ff0074-318c-9bac-e053-1705fe0af019
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7
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Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents, file e0ff0074-a4c4-9bac-e053-1705fe0af019
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7
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Highly Potent and Selective Dopamine D4 Receptor Antagonists Potentially Useful for the Treatment of Glioblastoma, file e1f2415e-8cad-4756-a869-c567ce855645
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7
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Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring, file e0ff0072-717d-9bac-e053-1705fe0af019
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6
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Investigating the role of the central melanocortin system in stress and stress-related disorders, file 29ffffa7-dea9-425d-8464-c2b7d73f689e
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5
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Underlying susceptibility to eating disorders and drug abuse: Genetic and pharmacological aspects of dopamine D4 receptors, file 923b0162-00a1-4a81-882c-3077570a192a
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5
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Biological profile and bioavailability of imidazoline compounds on morphine tolerance modulation, file e0ff0073-8b02-9bac-e053-1705fe0af019
|
4
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Treatment With 2-Pentadecyl-2-Oxazoline Restores Mild Traumatic Brain Injury-Induced Sensorial and Neuropsychiatric Dysfunctions, file 09e75f56-4140-46d3-a5bb-51c2423ab1f9
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3
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Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior, file 5e04e4a2-a83d-4e1e-bbc9-326d9f303565
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3
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Advances in the Development of Nonpeptide Small Molecules Targeting Ghrelin Receptor, file b3149c40-4dff-4f3f-8264-a4daed8b92ae
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3
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1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity, file e0ff0073-d820-9bac-e053-1705fe0af019
|
3
|
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Novel antitumor copper(ii) complexes designed to act through synergistic mechanisms of action, due to the presence of an NMDA receptor ligand and copper in the same chemical entity, file e0ff0074-d8cc-9bac-e053-1705fe0af019
|
3
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The Use of the Selective Imidazoline I1 Receptor Agonist Carbophenyline as a Strategy for Neuropathic Pain Relief: Preclinical Evaluation in a Mouse Model of Oxaliplatin-Induced Neurotoxicity, file df079acd-71c5-4d1e-b622-27d399e4b29f
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2
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Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement., file e0ff0072-468a-9bac-e053-1705fe0af019
|
2
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Structure−Activity Relationships in 1,4-Benzodioxan-Related Compounds. 11.1 Reversed Enantioselectivity of 1,4-Dioxane Derivatives in α1‑Adrenergic and 5‑HT1A Receptor Binding Sites Recognition, file e0ff0072-70db-9bac-e053-1705fe0af019
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2
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Low doses of allyphenyline and cyclomethyline, effective against morphine dependence, elicit an antidepressant-like effect, file e0ff0072-70e1-9bac-e053-1705fe0af019
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2
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Might the observed alpha2A-adrenoreceptor agonism or antagonism of allyphenyline analogues be ascribed to different molecular conformations?, file e0ff0072-7ad9-9bac-e053-1705fe0af019
|
2
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The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes, file e0ff0074-3cba-9bac-e053-1705fe0af019
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2
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Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation., file 07a1499b-ab7c-4d7e-81f2-f271703992bf
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1
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Recent findings leading to the discovery of selective dopamine D4 receptor ligands for the treatment of widespread diseases, file 9db4b1f2-c53b-432f-8eaa-b6eafe2d2120
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1
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Alpha2C-adrenoceptor modulators: a patent review, file e0ff0072-70e3-9bac-e053-1705fe0af019
|
1
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Synthesis and Biological Evaluation of a Novel Series of
Heterobivalent Muscarinic Ligands Based on Xanomeline and 1‑[3-
(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-
LH-28-1), file e0ff0072-70e4-9bac-e053-1705fe0af019
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1
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Novel triazolium based 11th group NHCs: synthesis, characterization and cellular response mechanisms, file e0ff0072-743c-9bac-e053-1705fe0af019
|
1
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Identification of 2-aminopyrimidine derivatives as inhibitors of the canonical Wnt signaling pathway, file e0ff0072-7ad6-9bac-e053-1705fe0af019
|
1
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1,4-Dioxane, a Suitable Scaffold for the Development of Novel M3 Muscarinic Receptor Antagonists, file e0ff0072-7adc-9bac-e053-1705fe0af019
|
1
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Novel Potent 5-HT1a Agonists Selective over alpha1-Adrenoceptor Subtypes, file e0ff0072-b98a-9bac-e053-1705fe0af019
|
1
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33rd Camerino-Cyprus Symposium - Receptor Chemistry: Reality and Vision, file e0ff0072-e565-9bac-e053-1705fe0af019
|
1
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New insights in Au-NHCs complexes as anticancer agents, file e0ff0073-0b42-9bac-e053-1705fe0af019
|
1
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Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells, file e0ff0074-1fff-9bac-e053-1705fe0af019
|
1
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Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia, file e0ff0074-49a0-9bac-e053-1705fe0af019
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1
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1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor, file e0ff0074-5611-9bac-e053-1705fe0af019
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1
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Activation of primary amines by copper(I)-based Lewis acid promoters in the solventless synthesis of secondary propargylamines, file e0ff0074-9e34-9bac-e053-1705fe0af019
|
1
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Zinc coordination complexes as anticancer agents, file e0ff0074-c15c-9bac-e053-1705fe0af019
|
1
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| Totale |
1.360 |