BONIFAZI, ALESSANDRO
BONIFAZI, ALESSANDRO
1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS
2013-01-01 Bonifazi, Alessandro; DEL BELLO, Fabio; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Pigini, Maria; Quaglia, Wilma; Thomas M., Keck; Amy H., Newman
1,4-Dioxane nucleus as a suitable scaffold in the building of ligands interacting with NMDA and σ1 receptors
2015-01-01 DEL BELLO, Fabio; Bonifazi, Alessandro; Piergentili, Alessandro; Quaglia, Wilma; Barocelli, Elisabetta; Vistoli, Giulio
1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor
2018-01-01 Del Bello, Fabio; Bonifazi, Alessandro; Giorgioni, Gianfabio; Cifani, Carlo; Micioni Di Bonaventura, Maria Vittoria; Petrelli, Riccardo; Piergentili, Alessandro; Fontana, Stefano; Mammoli, Valerio; Yano, Hideaki; Matucci, Rosanna; Vistoli, Giulio; Quaglia, Wilma
77-LH-28-1 as a model for the rational design of selective dopamine D4 receptor ligands
2017-01-01 DEL BELLO, Fabio; Bonifazi, Alessandro; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Quaglia, Wilma; Matucci, Rosanna
A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus
2016-01-01 Mammoli, Valerio; Bonifazi, Alessandro; DAL BEN, Diego; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Pigini, Maria; Quaglia, Wilma; Thomas, Ajiroghene; Newman, Amy H; Ferré, Sergi; Sanchez Soto, Marta; Keck, Thomas M; DEL BELLO, Fabio
Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells
2019-01-01 Del Bello, Fabio; Bonifazi, Alessandro; Giorgioni, Gianfabio; Quaglia, Wilma; Amantini, Consuelo; Morelli, Maria Beatrice; Santoni, Giorgio; Battiti, Francisco O; Vistoli, Giulio; Cilia, Antonio; Piergentili, Alessandro
Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation.
2014-01-01 Morelli, Mb; Amantini, Consuelo; Nabissi, Massimo; Liberati, Sonia; Cardinali, C; Farfariello, Valerio; Tomassoni, Daniele; Quaglia, Wilma; Piergentili, Alessandro; Bonifazi, Alessandro; DEL BELLO, Fabio; Santoni, M; Mammana, G; Servi, L; Filosa, A; Gismondi, A; Santoni, Giorgio
DOPAMINE D2, D3, AND D4 RECEPTOR AFFINITIES OF 77-LH-28-1 AND ITS ANALOGUES
2016-01-01 Piergentili, Alessandro; DEL BELLO, Fabio; Giannella, Mario; Giorgioni, Gianfabio; Quaglia, Wilma; Bonifazi, Alessandro; Ellenberger, Michael P.; Matucci, Rosanna
Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement.
2012-01-01 Mammoli, Valerio; Bonifazi, Alessandro; DEL BELLO, Fabio; Diamanti, Eleonora; Giannella, Mario; Hudson, Al; Mattioli, Laura; Perfumi, Marina Cecilia; Piergentili, Alessandro; Quaglia, Wilma; Titomanlio, Federica; Pigini, Maria
Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane
2019-01-01 Del Bello, Fabio; Micioni Di Bonaventura, Maria Vittoria; Bonifazi, Alessandro; Wünsch, Bernhard; Schepmann, Dirk; Giancola, JoLynn B; Micioni Di Bonaventura, Emanuela; Vistoli, Giulio; Giorgioni, Gianfabio; Quaglia, Wilma; Piergentili, Alessandro; Cifani, Carlo
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites
2014-01-01 DEL BELLO, Fabio; Bonifazi, Alessandro; Quaglia, Wilma; Angelica, Mazzolari; Elisabetta, Barocelli; Simona, Bertoni; Rosanna, Matucci; Marta, Nesi; Piergentili, Alessandro; Giulio, Vistoli
Molecular and Stereochemical Requirements of 1,4-Dioxane Ligands for the Interaction with Different Receptor Systems
2014-03-28 Bonifazi, Alessandro
Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia
2019-01-01 Del Bello, Fabio; Ambrosini, Dario; Bonifazi, Alessandro; Newman, Amy Hauck; Keck, Thomas M; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Cappellacci, Loredana; Cilia, Antonio; Franchini, Silvia; Quaglia, Wilma
Novel 1,4-dioxane derivatives as NMDA receptor channel blockers
2014-01-01 DEL BELLO, Fabio; Bonifazi, Alessandro; Quaglia, Wilma; Piergentili, Alessandro; Giannella, Mario; Pigini, Maria; Mammoli, Valerio; Giorgioni, Gianfabio; Cimarelli, Cristina; Pellei, Maura; B., Wünsch; D:, Schepmann
NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS
2013-01-01 Bonifazi, Alessandro; DEL BELLO, Fabio; Giannella, Mario; Mammoli, Valerio; Pigini, Maria; Piergentili, Alessandro; Quaglia, Wilma; Hideaki, Yano; Sergi, Ferré; Marta, Nesi; Rosanna, Matucci
Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments
2017-01-01 DEL BELLO, Fabio; Bonifazi, Alessandro; Giorgioni, Gianfabio; Petrelli, Riccardo; Quaglia, Wilma; Altomare, Angela; Falcicchio, Aurelia; Matucci, Rosanna; Vistoli, Giulio; Piergentili, Alessandro
Novel Potent 5-HT1a Agonists Selective over alpha1-Adrenoceptor Subtypes
2016-01-01 Quaglia, Wilma; DEL BELLO, Fabio; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Petrelli, Riccardo; Cifani, Carlo; Micioni Di Bonaventura, Maria Vittora; Newman, Amy H.; Bonifazi, Alessandro; Keck, Thomas M.; Vistoli, Giulio; Mazzolari, Angelica; Cilia, Antonio; Poggesi, Elena
Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring
2015-01-01 Bonifazi, Alessandro; DEL BELLO, Fabio; Mammoli, Valerio; Piergentili, Alessandro; Petrelli, Riccardo; Cimarelli, Cristina; Pellei, Maura; Schepmann, Dirk; Wünsch, Bernhard; Barocelli, Elisabetta; Bertoni, Simona; Flammini, Lisa; Amantini, Consuelo; Nabissi, Massimo; Santoni, Giorgio; Vistoli, Giulio; Quaglia, Wilma
Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells
2019-01-01 Morelli, Maria Beatrice; Amantini, Consuelo; Nabissi, Massimo; Santoni, Giorgio; Wünsch, Bernhard; Schepmann, Dirk; Cimarelli, Cristina; Pellei, Maura; Santini, Carlo; Fontana, Stefano; Mammoli, Valerio; Quaglia, Wilma; Bonifazi, Alessandro; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Del Bello, Fabio
Synthesis and Biological Evaluation of a Novel Series of Heterobivalent Muscarinic Ligands Based on Xanomeline and 1‑[3- (4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77- LH-28-1)
2014-01-01 Bonifazi, Alessandro; Yano, H.; DEL BELLO, Fabio; Farande, A.; Quaglia, Wilma; Petrelli, Riccardo; Matucci, R.; Nesi, M.; Vistoli, G.; Ferré, S.; Piergentili, Alessandro
| Titolo | Data di pubblicazione | Autore(i) | Tipo | File |
|---|---|---|---|---|
| 1,4-DIOXANE NUCLEUS AS A SUITABLE SCAFFOLD FOR NOVEL D2-LIKE RECEPTOR LIGANDS | 1-gen-2013 | Bonifazi, Alessandro; DEL BELLO, Fabio; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Pigini, Maria; Quaglia, Wilma; Thomas M., Keck; Amy H., Newman | Poster atto convegno su volume | |
| 1,4-Dioxane nucleus as a suitable scaffold in the building of ligands interacting with NMDA and σ1 receptors | 1-gen-2015 | DEL BELLO, Fabio; Bonifazi, Alessandro; Piergentili, Alessandro; Quaglia, Wilma; Barocelli, Elisabetta; Vistoli, Giulio | Contributo in atto di convegno su volume | |
| 1-[3-(4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77-LH-28-1) as a Model for the Rational Design of a Novel Class of Brain Penetrant Ligands with High Affinity and Selectivity for Dopamine D4 Receptor | 1-gen-2018 | Del Bello, Fabio; Bonifazi, Alessandro; Giorgioni, Gianfabio; Cifani, Carlo; Micioni Di Bonaventura, Maria Vittoria; Petrelli, Riccardo; Piergentili, Alessandro; Fontana, Stefano; Mammoli, Valerio; Yano, Hideaki; Matucci, Rosanna; Vistoli, Giulio; Quaglia, Wilma | Articolo | |
| 77-LH-28-1 as a model for the rational design of selective dopamine D4 receptor ligands | 1-gen-2017 | DEL BELLO, Fabio; Bonifazi, Alessandro; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Quaglia, Wilma; Matucci, Rosanna | Poster atto convegno su volume | |
| A Novel Class of Dopamine D4 Receptor Ligands Bearing an Imidazoline Nucleus | 1-gen-2016 | Mammoli, Valerio; Bonifazi, Alessandro; DAL BEN, Diego; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Pigini, Maria; Quaglia, Wilma; Thomas, Ajiroghene; Newman, Amy H; Ferré, Sergi; Sanchez Soto, Marta; Keck, Thomas M; DEL BELLO, Fabio | Articolo | |
| Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells | 1-gen-2019 | Del Bello, Fabio; Bonifazi, Alessandro; Giorgioni, Gianfabio; Quaglia, Wilma; Amantini, Consuelo; Morelli, Maria Beatrice; Santoni, Giorgio; Battiti, Francisco O; Vistoli, Giulio; Cilia, Antonio; Piergentili, Alessandro | Articolo | |
| Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation. | 1-gen-2014 | Morelli, Mb; Amantini, Consuelo; Nabissi, Massimo; Liberati, Sonia; Cardinali, C; Farfariello, Valerio; Tomassoni, Daniele; Quaglia, Wilma; Piergentili, Alessandro; Bonifazi, Alessandro; DEL BELLO, Fabio; Santoni, M; Mammana, G; Servi, L; Filosa, A; Gismondi, A; Santoni, Giorgio | Articolo | |
| DOPAMINE D2, D3, AND D4 RECEPTOR AFFINITIES OF 77-LH-28-1 AND ITS ANALOGUES | 1-gen-2016 | Piergentili, Alessandro; DEL BELLO, Fabio; Giannella, Mario; Giorgioni, Gianfabio; Quaglia, Wilma; Bonifazi, Alessandro; Ellenberger, Michael P.; Matucci, Rosanna | Contributo in atto di convegno su volume | |
| Favourable involvement of α2A-adrenoreceptor antagonism in the I₂-imidazoline binding sites-mediated morphine analgesia enhancement. | 1-gen-2012 | Mammoli, Valerio; Bonifazi, Alessandro; DEL BELLO, Fabio; Diamanti, Eleonora; Giannella, Mario; Hudson, Al; Mattioli, Laura; Perfumi, Marina Cecilia; Piergentili, Alessandro; Quaglia, Wilma; Titomanlio, Federica; Pigini, Maria | Articolo | |
| Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane | 1-gen-2019 | Del Bello, Fabio; Micioni Di Bonaventura, Maria Vittoria; Bonifazi, Alessandro; Wünsch, Bernhard; Schepmann, Dirk; Giancola, JoLynn B; Micioni Di Bonaventura, Emanuela; Vistoli, Giulio; Giorgioni, Gianfabio; Quaglia, Wilma; Piergentili, Alessandro; Cifani, Carlo | Articolo | |
| Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites | 1-gen-2014 | DEL BELLO, Fabio; Bonifazi, Alessandro; Quaglia, Wilma; Angelica, Mazzolari; Elisabetta, Barocelli; Simona, Bertoni; Rosanna, Matucci; Marta, Nesi; Piergentili, Alessandro; Giulio, Vistoli | Articolo | |
| Molecular and Stereochemical Requirements of 1,4-Dioxane Ligands for the Interaction with Different Receptor Systems | 28-mar-2014 | Bonifazi, Alessandro | Doctoral Thesis | |
| Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia | 1-gen-2019 | Del Bello, Fabio; Ambrosini, Dario; Bonifazi, Alessandro; Newman, Amy Hauck; Keck, Thomas M; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Cappellacci, Loredana; Cilia, Antonio; Franchini, Silvia; Quaglia, Wilma | Articolo | |
| Novel 1,4-dioxane derivatives as NMDA receptor channel blockers | 1-gen-2014 | DEL BELLO, Fabio; Bonifazi, Alessandro; Quaglia, Wilma; Piergentili, Alessandro; Giannella, Mario; Pigini, Maria; Mammoli, Valerio; Giorgioni, Gianfabio; Cimarelli, Cristina; Pellei, Maura; B., Wünsch; D:, Schepmann | Contributo in atto di convegno su volume | |
| NOVEL BIVALENT LIGANDS OF XANOMELINE AND 77-LH-28-1 AS POTENTIAL M1 MUSCARINIC AGONISTS | 1-gen-2013 | Bonifazi, Alessandro; DEL BELLO, Fabio; Giannella, Mario; Mammoli, Valerio; Pigini, Maria; Piergentili, Alessandro; Quaglia, Wilma; Hideaki, Yano; Sergi, Ferré; Marta, Nesi; Rosanna, Matucci | Poster atto convegno su volume | |
| Novel muscarinic acetylcholine receptor hybrid ligands embedding quinuclidine and 1,4-dioxane fragments | 1-gen-2017 | DEL BELLO, Fabio; Bonifazi, Alessandro; Giorgioni, Gianfabio; Petrelli, Riccardo; Quaglia, Wilma; Altomare, Angela; Falcicchio, Aurelia; Matucci, Rosanna; Vistoli, Giulio; Piergentili, Alessandro | Articolo | |
| Novel Potent 5-HT1a Agonists Selective over alpha1-Adrenoceptor Subtypes | 1-gen-2016 | Quaglia, Wilma; DEL BELLO, Fabio; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Petrelli, Riccardo; Cifani, Carlo; Micioni Di Bonaventura, Maria Vittora; Newman, Amy H.; Bonifazi, Alessandro; Keck, Thomas M.; Vistoli, Giulio; Mazzolari, Angelica; Cilia, Antonio; Poggesi, Elena | Contributo in atto di convegno su volume | |
| Novel Potent N-Methyl-d-aspartate (NMDA) Receptor Antagonists or σ1 Receptor Ligands Based on Properly Substituted 1,4-Dioxane Ring | 1-gen-2015 | Bonifazi, Alessandro; DEL BELLO, Fabio; Mammoli, Valerio; Piergentili, Alessandro; Petrelli, Riccardo; Cimarelli, Cristina; Pellei, Maura; Schepmann, Dirk; Wünsch, Bernhard; Barocelli, Elisabetta; Bertoni, Simona; Flammini, Lisa; Amantini, Consuelo; Nabissi, Massimo; Santoni, Giorgio; Vistoli, Giulio; Quaglia, Wilma | Articolo | |
| Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells | 1-gen-2019 | Morelli, Maria Beatrice; Amantini, Consuelo; Nabissi, Massimo; Santoni, Giorgio; Wünsch, Bernhard; Schepmann, Dirk; Cimarelli, Cristina; Pellei, Maura; Santini, Carlo; Fontana, Stefano; Mammoli, Valerio; Quaglia, Wilma; Bonifazi, Alessandro; Giannella, Mario; Giorgioni, Gianfabio; Piergentili, Alessandro; Del Bello, Fabio | Articolo | |
| Synthesis and Biological Evaluation of a Novel Series of Heterobivalent Muscarinic Ligands Based on Xanomeline and 1‑[3- (4-Butylpiperidin-1-yl)propyl]-1,2,3,4-tetrahydroquinolin-2-one (77- LH-28-1) | 1-gen-2014 | Bonifazi, Alessandro; Yano, H.; DEL BELLO, Fabio; Farande, A.; Quaglia, Wilma; Petrelli, Riccardo; Matucci, R.; Nesi, M.; Vistoli, G.; Ferré, S.; Piergentili, Alessandro | Articolo |