Polyamines activity in canine inflammatory colorectal polyps before and after a probiotic bacteria treatment

Recent researches demonstrate a correlation between polyamine intake or intestinal exposure, to risk of colorectal neoplasia (Vargas et al., 2012). Furthermore, the role of polyamines, spermidine (SPD) and spermine (SPM), and their precursor putrescine (PUT), regulated in their cellular levels by ornithine decarboxylase (ODC), in cell growth and proliferation is very well recognized. Increased polyamine levels are observed also in patients with IBD with their corresponding inflammatory index revealed that increased concentrations of polyamines found in the most severe inflamed mucosal areas. Some probiotics seem to have anti-inflammatory and tumor inhibitory properties, but few studies have investigated their actions on mucosal polyamine levels.