We Hydrazone compounds, bearing –CH=N–NH–C(O)– functional groups, are a special kind of Schiff bases which have extensive biological properties. In fact their chemistry is particularly intriguing due to their capability to easily furnish valuable chemotherapeutics such as anticancer, antibacterial, antifungal and antiprotozoal agents1 as well as enzyme inhibitors.2 As an extension of our research on acylpyrazolone chemistry3 and relative Ru-arene compounds4 the present work has the aim to design, synthesize and study the biological properties of new half-sandwich η6-arene-ruthenium(II) complexes with different 4-acyl-5-pyrazolone-based hydrazone scaffolds with general structure HL’ (Figure 1). Preliminary results on DNA vs BSA protein binding and on the effect as anti-Trypanosoma brucei parasite agents5 will be reported.
Synthesis and Biological Evaluations of Novel Arene Ru(II) Complexes of 4-acyl-5-pyrazolone-based Hydrazone Ligands
CONDELLO, FRANCESCA;PALMUCCI, JESSICA;PETRINI, Agnese;TORQUATI, ILARIA;PETRELLI, Riccardo;CAPPELLACCI, Loredana;LUPIDI, Giulio;PETTINARI, Riccardo;MARCHETTI, Fabio;PETTINARI, Claudio
2015-01-01
Abstract
We Hydrazone compounds, bearing –CH=N–NH–C(O)– functional groups, are a special kind of Schiff bases which have extensive biological properties. In fact their chemistry is particularly intriguing due to their capability to easily furnish valuable chemotherapeutics such as anticancer, antibacterial, antifungal and antiprotozoal agents1 as well as enzyme inhibitors.2 As an extension of our research on acylpyrazolone chemistry3 and relative Ru-arene compounds4 the present work has the aim to design, synthesize and study the biological properties of new half-sandwich η6-arene-ruthenium(II) complexes with different 4-acyl-5-pyrazolone-based hydrazone scaffolds with general structure HL’ (Figure 1). Preliminary results on DNA vs BSA protein binding and on the effect as anti-Trypanosoma brucei parasite agents5 will be reported.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
