Synthesis, Characterization, Catalytic Activity and Biological of New Arylhydrazones of Barbituric Acid Complexes with Co(II), Cu(II) and Ag(I)

Derivatives of barbituric acid show very interesting pharmaceutical properties unlike the barbituric acid that is pharmacologically inactive, due to the side group attached to the C5 atom of the pyrimidine ring. One of the most common method used for the functionalization of barbituric acid is the Japp-Klingemann reaction which leads to arylhydrazones of barbituric acid (AHBAs). Their coordination chemistry is still a little explored area of research, notwithstanding their interesting chemical and structural features. Coordination compounds with such ligands are already known, most of them being copper and zinc complexes.1 Therefore, here we report some novel complexes of Co(II), Cu(II) and Ag(I) containing AHBAs ligand and imidazole as an auxiliary ligand (Scheme). Results toward their catalytic, antimicrobial and biological activities will be also discussed in this report.