This study reports on the synthesis, characterization and peptide release behavior of a simultaneously physically and chemically crosslinked hydrogel. Thermosensitive methacrylate bearing polymers and thiolated hyaluronan were combined to prepare a biodegradable but structurally stable and biocompatible hydrogel system. This tandem system, displaying in situ physical gelation, triggered by temperature, and chemical gelation, through Michael type addition reaction between thiol and methacrylate groups, showed favorable properties for the diffusion-controlled delivery of peptides.
In-situ forming hydrogels by simultaneous thermal gelling and Michael addition reaction between methacrylate bearing thermosensitive triblock copolymers and thiolated hyaluronan
CENSI, Roberta;DI MARTINO, Piera;
2010-01-01
Abstract
This study reports on the synthesis, characterization and peptide release behavior of a simultaneously physically and chemically crosslinked hydrogel. Thermosensitive methacrylate bearing polymers and thiolated hyaluronan were combined to prepare a biodegradable but structurally stable and biocompatible hydrogel system. This tandem system, displaying in situ physical gelation, triggered by temperature, and chemical gelation, through Michael type addition reaction between thiol and methacrylate groups, showed favorable properties for the diffusion-controlled delivery of peptides.File in questo prodotto:
Non ci sono file associati a questo prodotto.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
