Environmental factors interface the genotype-phenotype correlation and result conferring a stable memory of activity status of genes. Early-life exposure (postnatal day 6-21) to low doses of the pesticide permethrin leads to down regulation of Nurr1 expression and also dopamine levels. This is correlated with hyper methylation of CpG in the promoter region of Nurr1 in adolescent rats exposed to permethrin while no alteration in methylation was seen in the age-matched control group. In order to define the mechanisms associated with the decreased Nurr1 gene expression, DNMTs and -synuclein levels were measured in adolescent, adult and old rats. The results obtained confirm their imbalance depending on the treatment and the age of rats.

α-synuclein and DNMT imbalance, following early life permethrin treatment, leads to Nurr1 down regulation

GABBIANELLI, Rosita;FEDELI, Donatella;MONTANI, Maura;NASUTI, Cinzia Carla;
2014-01-01

Abstract

Environmental factors interface the genotype-phenotype correlation and result conferring a stable memory of activity status of genes. Early-life exposure (postnatal day 6-21) to low doses of the pesticide permethrin leads to down regulation of Nurr1 expression and also dopamine levels. This is correlated with hyper methylation of CpG in the promoter region of Nurr1 in adolescent rats exposed to permethrin while no alteration in methylation was seen in the age-matched control group. In order to define the mechanisms associated with the decreased Nurr1 gene expression, DNMTs and -synuclein levels were measured in adolescent, adult and old rats. The results obtained confirm their imbalance depending on the treatment and the age of rats.
2014
0000000000
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/359382
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact