Ruthenium-arene complxes are considered valid alternatives to platinum drugs, owing to their lower toxicity and stronger selectivity. Since curcumin possesses anti-inflamatory, antioxidant and antitumoral effects, it has been extensively studied as a chemo preventive agent in some cancer models. As continuation of our previous work, a series of novel Ru(II) arene RAPTA type derivatives (areme = cymene and hexamethylbenzene) containing corcumin-based ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and PTA (1,3,5-triaza-7-phosphaadamantane) has been synthesized and fully characterized. The antitumor activity of the complexes has been evaluated in vitroagainst human ovarian carcinoma cells, A2780 and A2780cisR, as well as against non-tumorous Human Embryonic Kidney (HEK293) cells.
Selective Anticancer Ruthenium(II) Arene RAPTA Type Complexes Containing Curcuminoids
CONDELLO, FRANCESCA;ORBISAGLIA, SERENA;PALMUCCI, JESSICA;PETRINI, Agnese;PETTINARI, Riccardo;MARCHETTI, Fabio;PETTINARI, Claudio;
2014-01-01
Abstract
Ruthenium-arene complxes are considered valid alternatives to platinum drugs, owing to their lower toxicity and stronger selectivity. Since curcumin possesses anti-inflamatory, antioxidant and antitumoral effects, it has been extensively studied as a chemo preventive agent in some cancer models. As continuation of our previous work, a series of novel Ru(II) arene RAPTA type derivatives (areme = cymene and hexamethylbenzene) containing corcumin-based ligands (curcH = curcumin, bdcurcH = bisdemethoxycurcumin) and PTA (1,3,5-triaza-7-phosphaadamantane) has been synthesized and fully characterized. The antitumor activity of the complexes has been evaluated in vitroagainst human ovarian carcinoma cells, A2780 and A2780cisR, as well as against non-tumorous Human Embryonic Kidney (HEK293) cells.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
