The nucleophilic addition of an organometallic reagent to multiple bonds is one of the most important strategies to obtain new bonds. The usefulness of this reaction is of marked importance not only for organometallic chemists but also in organic chemistry and in the synthesis of complex organic molecules. However, in spite of its broad utility, their basicity and redox potential sometimes cause serious drawbacks to organometallic reagents. In this scenario, cerium(III) salts, when used as additives in combination with common organometallic reagents such as organolithium or Grignard reagents, emerged as reagents of choice in metal-promoted reactions allowing straightforward formation of carbon-carbon bonds. The reaction with organocerium reagents is now one of most frequently used in academic institutions or in industry because these compounds are environmentally sound compared to other organometallic reagents, and this has been an important aspect of their continued development.
Organocerium Reagents
MARCANTONI, Enrico;
2014-01-01
Abstract
The nucleophilic addition of an organometallic reagent to multiple bonds is one of the most important strategies to obtain new bonds. The usefulness of this reaction is of marked importance not only for organometallic chemists but also in organic chemistry and in the synthesis of complex organic molecules. However, in spite of its broad utility, their basicity and redox potential sometimes cause serious drawbacks to organometallic reagents. In this scenario, cerium(III) salts, when used as additives in combination with common organometallic reagents such as organolithium or Grignard reagents, emerged as reagents of choice in metal-promoted reactions allowing straightforward formation of carbon-carbon bonds. The reaction with organocerium reagents is now one of most frequently used in academic institutions or in industry because these compounds are environmentally sound compared to other organometallic reagents, and this has been an important aspect of their continued development.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
