The reaction of sulfonylpyrroles with nitroalkanes in the presence of KF/alumina generates 3-(2-nitroalkyl)pyrroles in good yields. These compounds can be converted into trisubstituted 6-azaindoles by a sequence of reactions comprising reduction of the nitro group, Pictet–Spengler cyclization and final oxidative aromatization.

Synthesis of 3-(2-Nitroalkyl)pyrroles from Sulfonylpyrroles and their Conversion to 6-Azaindole Derivatives

LANCIANESI, STEFANO;PALMIERI, Alessandro;PETRINI, Marino
2013-01-01

Abstract

The reaction of sulfonylpyrroles with nitroalkanes in the presence of KF/alumina generates 3-(2-nitroalkyl)pyrroles in good yields. These compounds can be converted into trisubstituted 6-azaindoles by a sequence of reactions comprising reduction of the nitro group, Pictet–Spengler cyclization and final oxidative aromatization.
2013
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/289181
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