The electrochemical behavior of 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-Proline (Captopril) was studied by cyclic voltammetry (CV). The influence of pH on the diffusion waves and the parameters associated with them were studied. The diffusion waves exhibit a quasi-reversible mechanism at low pH (under pH = 6.5) and an irreversible electron transfer at higher pH values. Product adsorption waves (prepeaks) showing marked reversible behavior were observed and studied only at a pH of 2.20. Various parameters such as electron transfer rate (Ksh), maximum surface excess concentration (Γt), electron transfer coefficient (α), Frumkin's interaction parameter, (g) and diffusion coefficient (Dr) were calculated.
Voltammetry of captopril on Hanging mercury drop electrode
PASSAMONTI, Paolo;FERRARO, Stefano;
1991-01-01
Abstract
The electrochemical behavior of 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-Proline (Captopril) was studied by cyclic voltammetry (CV). The influence of pH on the diffusion waves and the parameters associated with them were studied. The diffusion waves exhibit a quasi-reversible mechanism at low pH (under pH = 6.5) and an irreversible electron transfer at higher pH values. Product adsorption waves (prepeaks) showing marked reversible behavior were observed and studied only at a pH of 2.20. Various parameters such as electron transfer rate (Ksh), maximum surface excess concentration (Γt), electron transfer coefficient (α), Frumkin's interaction parameter, (g) and diffusion coefficient (Dr) were calculated.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
