The last ten years have witnessed a remarkable increase in our awareness of the importance of events subsequent to transcriptional initiation in terms of the regulation and control of gene expression. In particular, the development of recombinant DNA techniques begun in the 1970s provided powerful new tools with which to study the molecular basis of control and regulation at all lev- els. This up-to-date guide discusses the post-transcriptional processes controlling and regulating gene expression in eucaryotes and procaryotes. The topics covered include transcriptional (anti)termination, mRNA stability, anti-sense RNA, translational control and translational fidelity. An understanding of these mechanisms is an essential requirement for the optimisation of gene expression in various biotechnological applications.
The function of initiation factors in relation to mRNA-ribosome interaction and regulation of gene expression.
FALCONI, Maurizio;SPURIO, Roberto;PON, Cynthia;GUALERZI, Claudio
1990-01-01
Abstract
The last ten years have witnessed a remarkable increase in our awareness of the importance of events subsequent to transcriptional initiation in terms of the regulation and control of gene expression. In particular, the development of recombinant DNA techniques begun in the 1970s provided powerful new tools with which to study the molecular basis of control and regulation at all lev- els. This up-to-date guide discusses the post-transcriptional processes controlling and regulating gene expression in eucaryotes and procaryotes. The topics covered include transcriptional (anti)termination, mRNA stability, anti-sense RNA, translational control and translational fidelity. An understanding of these mechanisms is an essential requirement for the optimisation of gene expression in various biotechnological applications.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
