The reaction of nitroalkanes with 2-chloro-3-phenylsulfonylpropanenitrile, in the presence of three equivalents of DBU at −10°C, allows the synthesis of polyfunctionalized α,β-unsaturated nitriles. The method proceeds through three different reactions carried out in a tandem sequence, allowing the one-pot formation of the α,β-unsaturated nitriles, generally, with complete E stereochemistry.

One-pot synthesis of polyfunctionalized, alpha, beta-unsaturated nitriles from nitroalkanes

BALLINI, Roberto;FIORINI, Dennis;PALMIERI, Alessandro
2003-01-01

Abstract

The reaction of nitroalkanes with 2-chloro-3-phenylsulfonylpropanenitrile, in the presence of three equivalents of DBU at −10°C, allows the synthesis of polyfunctionalized α,β-unsaturated nitriles. The method proceeds through three different reactions carried out in a tandem sequence, allowing the one-pot formation of the α,β-unsaturated nitriles, generally, with complete E stereochemistry.
2003
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/242323
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