A lot of efforts have been directed over last years towards R&D of new metal-based anticancer drugs. Among non-Pt compounds, copper complexes are potentially attractive as anticancer agents. In this field, various hydrophilic "CuP4" complexes have been recently synthesized and [Cu(thp)4]PF6 has been shown to be more potent than cisplatin against different human tumour cells. Chemosensitivity tests suggested that [Cu(thp)4]PF6 besides not being potential MDR substrate, acted through a different mechanism of action than cisplatin. Cytological stains and FACS analyses indicated that [Cu(thp)4}PF6 inhibited cell growth via G2/M cell cycle arrest and extensive cellular vacuolization accompanied with the loss of mitochondrial transmembrane potential and polyubiquitinated protein accumulation.

Non apoptotic programmed cell death induced by a phosphine copper(I) complex as a new tool for overcoming cisplatin and multi drug resistence

M. PELLEI;SANTINI, Carlo;
2009-01-01

Abstract

A lot of efforts have been directed over last years towards R&D of new metal-based anticancer drugs. Among non-Pt compounds, copper complexes are potentially attractive as anticancer agents. In this field, various hydrophilic "CuP4" complexes have been recently synthesized and [Cu(thp)4]PF6 has been shown to be more potent than cisplatin against different human tumour cells. Chemosensitivity tests suggested that [Cu(thp)4]PF6 besides not being potential MDR substrate, acted through a different mechanism of action than cisplatin. Cytological stains and FACS analyses indicated that [Cu(thp)4}PF6 inhibited cell growth via G2/M cell cycle arrest and extensive cellular vacuolization accompanied with the loss of mitochondrial transmembrane potential and polyubiquitinated protein accumulation.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/200506
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