N6-Cycloalkyl-2′,3′-dideoxyadenosine derivatives and (2-chloro)-N6-cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV). Most compounds demonstrated good antireplicative activity against MVV, showing also low cell toxicity.
Deaza- and deoxyadenosine derivatives: synthesis and inhibition of animal viruses as human infectious models
VITTORI, Sauro;VOLPINI, Rosaria;VINCENZETTI, Silvia;VITA, Alberto;LAMBERTUCCI, Catia;CRISTALLI, Gloria
2003-01-01
Abstract
N6-Cycloalkyl-2′,3′-dideoxyadenosine derivatives and (2-chloro)-N6-cycloheptyl-3-deazaadenosine have been synthesized and tested, along with other (deaza)purine (deoxy)nucleosides from our chemical library, as inhibitors of virus replication against Bovine Herpes Virus 1 (BHV-1) and sheep Maedi/Visna Virus (MVV). Most compounds demonstrated good antireplicative activity against MVV, showing also low cell toxicity.File in questo prodotto:
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