3′-C-Methyladenosine (3′-Me-Ado) is a mechanism-based ribonucleotide reductase inhibitor endowed with antitumor activity against both human leukemia and carcinoma cell lines. In this paper, we report the synthesis and antitumor evaluation of a series of purine and pyrimidine 3′-C-methylribonucleoside analogs of 3′-Me-Ado. A stereoselective synthesis of the arabino analog of 3′-Me-Ado is also described. Among the tested compounds, only 3′-C-methyluridine showed moderate antitumor activity against human myelogenous leukemia K562 cell line

Purine and pyrimidine nucleoside analogs of 3'-C-methyladenosine as antitumor agents

CAPPELLACCI, Loredana;FRANCHETTI, Palmarisa;PETRELLI, Riccardo;VITA, PATRIZIA;GRIFANTINI, Mario
2006-01-01

Abstract

3′-C-Methyladenosine (3′-Me-Ado) is a mechanism-based ribonucleotide reductase inhibitor endowed with antitumor activity against both human leukemia and carcinoma cell lines. In this paper, we report the synthesis and antitumor evaluation of a series of purine and pyrimidine 3′-C-methylribonucleoside analogs of 3′-Me-Ado. A stereoselective synthesis of the arabino analog of 3′-Me-Ado is also described. Among the tested compounds, only 3′-C-methyluridine showed moderate antitumor activity against human myelogenous leukemia K562 cell line
2006
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11581/113431
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