Sfoglia per Autore
Synthesis, Absolute Configuration and Antimuscarinic Activity of the Enantiomers of [1-(2,2-Diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine.
2001-01-01 Gulini, Ugo; Angeli, Piero; Marucci, Gabriella; Buccioni, Michela; Giardina', Dario; Antolini, L; Franchini, S; Sorbi, C; Brasili, L.
Structure-Activity Relationships in 2,2-Diphenyl-2-ethylthioacetic Acid Esters: Unexpected Agonist Activity in a Series of Muscarinic Antagonists.
2001-01-01 Scapecchi, S.; Marucci, Gabriella; Matucci, R.; Angeli, Piero; Bellucci, C.; Buccioni, Michela; Dei, S.; Gualtieri, F.; Manetti, D.; Romanelli, M. N.; Teodori, E.
Analogues of Prazosin That Bear a Benextramine-Related Polyamine Backbone Exhibit Different Antagonism toward alpha1-Adrenoceptor Subtypes
2001-01-01 Bolognesi, M. L.; Marucci, Gabriella; Angeli, Piero; Buccioni, Michela; Minarini, A.; Rosini, M.; Tumiatti, V.; Melchiorre, C.
Structure-activity relationships among novel phenoxybenzamine-related beta-chloroethylamines
2002-01-01 Giardina', Dario; Crucianelli, M.; Angeli, Piero; Buccioni, M.; Gulini, Ugo; Marucci, Gabriella; Sagratini, Gianni; Melchiorre, C.
Structure-Activity Relatioships Among Novel Phenoxybenzamine-Related Beta-Chloroethylamines.
2002-01-01 Giardina', Dario; Crucianelli, M; Angeli, Piero; Marucci, Gabriella; Buccioni, Michela; Gulini, Ugo; Sagratini, Gianni; Melchiorre, C.
Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors.
2002-01-01 Angeli, Piero; Marucci, Gabriella; Buccioni, Michela; Piergentili, Alessandro; Giannella, Mario; Quaglia, Wilma; Pigini, Maria; Cantalamessa, Franco; Nasuti, Cinzia Carla; Novi, F; Maggio, R; Quasem, A. R.; Spampinato, S.
Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of their iodomethylates.
2003-01-01 Dei, S; Bellucci, C; Buccioni, Michela; Ferrarono, M; Gualtieri, F; Guandalini, L; Manetti, D; Matucci, R; Romanelli, M. N.; Scapecchi, S; Teodori, E.
Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol
2003-01-01 Varoli, L; Angeli, Piero; Buccioni, Michela; Burnelli, S; Cavalli, A; Marucci, Gabriella; Recanatini, M.
Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity.
2004-01-01 Scapecchi, S; Martini, E; Bellucci, C; Buccioni, Michela; Dei, S; Guandalini, L; Manetti, D; Martelli, C; Marucci, Gabriella; Matucci, R.
(+)-Cyclazosin Derivatives as alpha1-Adrenoceptor Antagonists
2004-01-01 Sagratini, G; Marucci, G; Buccioni, Michela; Gulini, U; Marucci, G; Melchiorre, C; Leonardi, A; Testa, R; Giardin, D.
(+)-Cyclazosin derivatives as α1-adrenoceptor antagonists
2004-01-01 Sagratini, Gianni; Buccioni, Michela; Gulini, U.; Marucci, Gabriella; Melchiorre, C.; Leonardi, A.; Testa, R.; Giardinà, D.
Molecular modulation of muscarinic antagonists. Synthesis and pharmacological profile of 2,2-diphenyl-2-ethylthioacetic and 3,3-diphenyl-3-ethylthiopropionic acid derivatives characterized by a dipeptide spacer.
2004-01-01 S., Scapecchi; C., Martelli; Angeli, Piero; C., Bellucci; Buccioni, Michela; S., Dei; F., Gualtieri; Marucci, Gabriella; R., Matucci; M. N., Romanelli; E., Teodori
Polyamines may modulate both G protein-coupled receptors and G proteins.
2004-01-01 Marucci, Gabriella; Novi, F; Banzi, R; Bolognesi, M. L.; Buccioni, Michela; Minarini, A; Rosini, M; Angeli, Piero; Maggio, R; Melchiorre, C.
1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands
2005-01-01 Tait, A; Luppi, A; Franchini, S; Preziosi, E; Parenti, C; Buccioni, Michela; Marucci, Gabriella; Leonardi, A; Poggesi, E; Brasili, L.
(+)-Cyclazosin, a selective alpha1B-adrenoceptor antagonist: Functional evaluation in rat and rabbit tissues
2005-01-01 Marucci, Gabriella; Angeli, Piero; Buccioni, Michela; Gulini, Ugo; Melchiorre, C; Sagratini, Gianni; Testa, R; Giardina', Dario
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation
2005-01-01 Quaglia, Wilma; Santoni, Giorgio; Pigini, Maria; Piergentili, Alessandro; Gentili, Francesco; Buccioni, Michela; Mosca, Michela; Lucciarini, Roberta; Amantini, Consuelo; Nabissi, Massimo; Ballarini, P; Poggesi, E; Leonardi, A; Ballarini, Patrizia
Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives
2005-01-01 Dei, S.; Angeli, Piero; Bellucci, C.; Buccioni, Michela; Gualtieri, F.; Marucci, Gabriella; Manetti, D.; Matucci, R.; Romanelli, M. N.
New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: High affinity ligands for the alpha-adrenoceptor subtypes
2006-01-01 Romeo, G.; Materia, L.; Marucci, Gabriella; Modica, M.; Pittala', V.; Salerno, L.; Siracusa, M. A.; Buccioni, Michela; Angeli, Piero; Minneman, K. P.
Highly chiral muscarinic ligands: The discovery of (2S,2 ' R,3 ' S,5 ' R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M-2 partial agonist
2006-01-01 Scapecchi, S; Matucci, R; Bellucci, C; Buccioni, Michela; Dei, S; Guandalini, L; Martelli, C; Manetti, D; Martini, E; Marucci, Gabriella; Nesi, M; Romanelli, M. N.; Teodori, E; Gualtieri, F.
Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure
2007-01-01 Dei, S.; Bellucci, C.; Buccioni, Michela; Ferraroni, M.; Guandalini, L.; Manetti, D.; Martini, E.; Marucci, Gabriella; Matucci, R.; Nesi, M.; Romanelli, M. N.; Scapecchi, S.; Teodori, E.
| Titolo | Data di pubblicazione | Autore(i) | Tipo | File |
|---|---|---|---|---|
| Synthesis, Absolute Configuration and Antimuscarinic Activity of the Enantiomers of [1-(2,2-Diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine. | 1-gen-2001 | Gulini, Ugo; Angeli, Piero; Marucci, Gabriella; Buccioni, Michela; Giardina', Dario; Antolini, L; Franchini, S; Sorbi, C; Brasili, L. | Articolo | |
| Structure-Activity Relationships in 2,2-Diphenyl-2-ethylthioacetic Acid Esters: Unexpected Agonist Activity in a Series of Muscarinic Antagonists. | 1-gen-2001 | Scapecchi, S.; Marucci, Gabriella; Matucci, R.; Angeli, Piero; Bellucci, C.; Buccioni, Michela; Dei, S.; Gualtieri, F.; Manetti, D.; Romanelli, M. N.; Teodori, E. | Articolo | |
| Analogues of Prazosin That Bear a Benextramine-Related Polyamine Backbone Exhibit Different Antagonism toward alpha1-Adrenoceptor Subtypes | 1-gen-2001 | Bolognesi, M. L.; Marucci, Gabriella; Angeli, Piero; Buccioni, Michela; Minarini, A.; Rosini, M.; Tumiatti, V.; Melchiorre, C. | Articolo | |
| Structure-activity relationships among novel phenoxybenzamine-related beta-chloroethylamines | 1-gen-2002 | Giardina', Dario; Crucianelli, M.; Angeli, Piero; Buccioni, M.; Gulini, Ugo; Marucci, Gabriella; Sagratini, Gianni; Melchiorre, C. | Articolo | |
| Structure-Activity Relatioships Among Novel Phenoxybenzamine-Related Beta-Chloroethylamines. | 1-gen-2002 | Giardina', Dario; Crucianelli, M; Angeli, Piero; Marucci, Gabriella; Buccioni, Michela; Gulini, Ugo; Sagratini, Gianni; Melchiorre, C. | Articolo | |
| Deoxamuscaroneoxime Devatives as useful Muscarinic Aginist to Explore the Muscarinic Subsite: Demox, Amodulator of Orthosteric and Allosteric Site at Cardiac Muscarinic M2 Receptors. | 1-gen-2002 | Angeli, Piero; Marucci, Gabriella; Buccioni, Michela; Piergentili, Alessandro; Giannella, Mario; Quaglia, Wilma; Pigini, Maria; Cantalamessa, Franco; Nasuti, Cinzia Carla; Novi, F; Maggio, R; Quasem, A. R.; Spampinato, S. | Articolo | |
| Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of their iodomethylates. | 1-gen-2003 | Dei, S; Bellucci, C; Buccioni, Michela; Ferrarono, M; Gualtieri, F; Guandalini, L; Manetti, D; Matucci, R; Romanelli, M. N.; Scapecchi, S; Teodori, E. | Articolo | |
| Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol | 1-gen-2003 | Varoli, L; Angeli, Piero; Buccioni, Michela; Burnelli, S; Cavalli, A; Marucci, Gabriella; Recanatini, M. | Articolo | |
| Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity. | 1-gen-2004 | Scapecchi, S; Martini, E; Bellucci, C; Buccioni, Michela; Dei, S; Guandalini, L; Manetti, D; Martelli, C; Marucci, Gabriella; Matucci, R. | Articolo | |
| (+)-Cyclazosin Derivatives as alpha1-Adrenoceptor Antagonists | 1-gen-2004 | Sagratini, G; Marucci, G; Buccioni, Michela; Gulini, U; Marucci, G; Melchiorre, C; Leonardi, A; Testa, R; Giardin, D. | Articolo | |
| (+)-Cyclazosin derivatives as α1-adrenoceptor antagonists | 1-gen-2004 | Sagratini, Gianni; Buccioni, Michela; Gulini, U.; Marucci, Gabriella; Melchiorre, C.; Leonardi, A.; Testa, R.; Giardinà, D. | Articolo | |
| Molecular modulation of muscarinic antagonists. Synthesis and pharmacological profile of 2,2-diphenyl-2-ethylthioacetic and 3,3-diphenyl-3-ethylthiopropionic acid derivatives characterized by a dipeptide spacer. | 1-gen-2004 | S., Scapecchi; C., Martelli; Angeli, Piero; C., Bellucci; Buccioni, Michela; S., Dei; F., Gualtieri; Marucci, Gabriella; R., Matucci; M. N., Romanelli; E., Teodori | Articolo | |
| Polyamines may modulate both G protein-coupled receptors and G proteins. | 1-gen-2004 | Marucci, Gabriella; Novi, F; Banzi, R; Bolognesi, M. L.; Buccioni, Michela; Minarini, A; Rosini, M; Angeli, Piero; Maggio, R; Melchiorre, C. | Articolo | |
| 1,2,4-Benzothiadiazine derivatives as alpha1 and 5-HT1A receptor ligands | 1-gen-2005 | Tait, A; Luppi, A; Franchini, S; Preziosi, E; Parenti, C; Buccioni, Michela; Marucci, Gabriella; Leonardi, A; Poggesi, E; Brasili, L. | Articolo | |
| (+)-Cyclazosin, a selective alpha1B-adrenoceptor antagonist: Functional evaluation in rat and rabbit tissues | 1-gen-2005 | Marucci, Gabriella; Angeli, Piero; Buccioni, Michela; Gulini, Ugo; Melchiorre, C; Sagratini, Gianni; Testa, R; Giardina', Dario | Articolo | |
| Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4 chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation | 1-gen-2005 | Quaglia, Wilma; Santoni, Giorgio; Pigini, Maria; Piergentili, Alessandro; Gentili, Francesco; Buccioni, Michela; Mosca, Michela; Lucciarini, Roberta; Amantini, Consuelo; Nabissi, Massimo; Ballarini, P; Poggesi, E; Leonardi, A; Ballarini, Patrizia | Articolo | |
| Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives | 1-gen-2005 | Dei, S.; Angeli, Piero; Bellucci, C.; Buccioni, Michela; Gualtieri, F.; Marucci, Gabriella; Manetti, D.; Matucci, R.; Romanelli, M. N. | Articolo | |
| New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: High affinity ligands for the alpha-adrenoceptor subtypes | 1-gen-2006 | Romeo, G.; Materia, L.; Marucci, Gabriella; Modica, M.; Pittala', V.; Salerno, L.; Siracusa, M. A.; Buccioni, Michela; Angeli, Piero; Minneman, K. P. | Articolo | |
| Highly chiral muscarinic ligands: The discovery of (2S,2 ' R,3 ' S,5 ' R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M-2 partial agonist | 1-gen-2006 | Scapecchi, S; Matucci, R; Bellucci, C; Buccioni, Michela; Dei, S; Guandalini, L; Martelli, C; Manetti, D; Martini, E; Marucci, Gabriella; Nesi, M; Romanelli, M. N.; Teodori, E; Gualtieri, F. | Articolo | |
| Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure | 1-gen-2007 | Dei, S.; Bellucci, C.; Buccioni, Michela; Ferraroni, M.; Guandalini, L.; Manetti, D.; Martini, E.; Marucci, Gabriella; Matucci, R.; Nesi, M.; Romanelli, M. N.; Scapecchi, S.; Teodori, E. | Articolo |
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